70398-87-7

Basic information

• Product Name: Benzene, 1-bromo-3-[(1-methylethyl)thio]-
• CAS NO: 70398-87-7
• Molecular Formula: C9H11BrS
• Molecular Weight: 231.156
• Mol File: 70398-87-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzene, 1-bromo-3-[(1-methylethyl)thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-bromo-3-[(1-methylethyl)thio]-(70398-87-7)
• EPA Substance Registry System: Benzene, 1-bromo-3-[(1-methylethyl)thio]-(70398-87-7)

Safety Data

• Hazardous Substances Data: 70398-87-7(Hazardous Substances Data)

Upstream product

• 6320-01-0 3-Bromothiophenol 
• 75-26-3 isopropyl bromide 
• 75-30-9 2-iodo-propane 
• 1073-06-9 3-fluorobromobenzene 
• 20607-43-6 sodium isopropanethiolate 

Downstream Products

• 1414778-06-5 cyclopropyl-(3-isopropylsulfanylphenyl)methanone 
• 1430328-43-0 C₁₇H₂₇NO₂S 
• 1430328-33-8 4-(3-isopropylsulfonylphenyl)piperidine 
• 1430328-32-7 methyl 4-(3-isopropylsulfonylphenyl)-3,6-dihydro-2H-pyridine-1-carboxylate 
• 1430328-31-6 4-(3-isopropylsulfanylphenyl)-1,2,3,6-tetrahydropyridine 
• 70399-01-8 1-bromo-3-(isopropylsulfonyl)benzene 

Relevant articles and documents

Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics**

Protein arginine N-methyl transferase 4 (PRMT4) asymmetrically dimethylates the arginine residues of histone H3 and nonhistone proteins. The overexpression of PRMT4 in several cancers has stimulated interest in the discovery of inhibitors as biological tools and, potentially, therapeutics. Although several PRMT4 inhibitors have been reported, most display poor selectivity against other members of the PRMT family of methyl transferases. Herein, we report the structure-based design of a new class of alanine-containing 3-arylindoles as potent and selective PRMT4 inhibitors, and describe key structure–activity relationships for this class of compounds.

AMINE DERIVATIVES AS POTASSIUM CHANNEL BLOCKERS

The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.

BENZOFURAN DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS

The invention relates to novel heterocycles of formula (I), processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.