704-00-7 Usage
Description
1,2-Diacetylbenzene is an aromatic hydrocarbon that serves as a protein-reactive γ-diketone metabolite of the neurotoxic solvent 1,2-diethylbenzene.
Uses
Used in Chemical Research:
1,2-Diacetylbenzene is used as a research compound for studying its metabolic pathways and potential effects on biological systems, particularly its role as a metabolite of the neurotoxic solvent 1,2-diethylbenzene.
Used in Pharmaceutical Development:
1,2-Diacetylbenzene is used as a starting material or intermediate in the synthesis of pharmaceutical compounds, given its unique chemical structure and reactivity with proteins.
Used in Environmental Monitoring:
1,2-Diacetylbenzene can be used as a biomarker for the presence of neurotoxic solvents in the environment, helping to monitor and control exposure to harmful substances.
Used in Toxicological Studies:
1,2-Diacetylbenzene is used as a subject in toxicological research to understand its potential health risks and to develop methods for mitigating the effects of neurotoxic solvents.
Purification Methods
Purify it by distilling and by recrystallising from pet ether. The bis-2,4-dinitrophenylhydrazone has m 221o (dec). [Halford & Weissmann J Org Chem 17 1646 1952, Riemschneider & Kassahn Chem Ber 92 1705 1959,[Beilstein 7 III 3501, 7 IV 2155.]
Check Digit Verification of cas no
The CAS Registry Mumber 704-00-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,0 and 4 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 704-00:
(5*7)+(4*0)+(3*4)+(2*0)+(1*0)=47
47 % 10 = 7
So 704-00-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H10O2/c1-7(11)9-5-3-4-6-10(9)8(2)12/h3-6H,1-2H3
704-00-7Relevant articles and documents
Generation and reaction of metal-containing carbonyl ylides: Tandem [3+2]-cycloaddition-carbene insertion leading to novel polycyclic compounds [1]
Iwasawa,Shido,Kusama
, p. 5814 - 5815 (2001)
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Simple Aza -conjugate addition methodology for the synthesis of isoindole nitrones and 3,4-dihydroisoquinoline nitrones
Peacock, Lucy R.,Chapman, Robert S. L.,Sedgwick, Adam C.,Bull, Steven D.,Mahon, Mary F.,Amans, Dominique
supporting information, p. 994 - 997 (2015/03/18)
Aryl-aldehydes containing ortho-substituted α,β-unsaturated carboxylic acid derivatives react with hydroxylamine to afford reactive N-hydroxy-carbinolamine intermediates that undergo intramolecular aza-conjugate addition reactions to afford isoindole nitrones and 3,4-dihydroisoquinoline nitrones in good yield. Conditions have been developed to reduce these isoindole nitrones to their corresponding hydroxylamine, enamine, and amine derivatives. Isoindole nitrones react with dimethyl acetylenedicarboxylate (DMAD) via a [4 + 2]-cycloaddition/deamination pathway to afford substituted naphthalene derivatives, while 3,4-dihydroisoquinoline nitrones react with DMAD via a [1,3]-dipolar cycloaddition pathway to afford tricyclic heteroarenes.
Preparation of 1,2-diacylbenzenes from o-hydroxyaryl ketone acylhydrazones using cross-linked poly[styrene(iodoso diacetate)]
Xian, Huang,Qing, Zhu,Jizheng, Zhang
, p. 2413 - 2418 (2007/10/03)
The 2 percent cross-linked poly[styrene(iodoso diacetate)] was used to synthesis of 1,2-diacylbenzenes, which gave high yields, and could be recycled.