704-38-1 Usage
Description
BIS(2-THIENYL) KETONE, also known as Tiotropium EP Impurity F, is a light brown crystalline powder with unique chemical properties. It is a significant compound in the pharmaceutical industry due to its involvement in the synthesis of various therapeutic agents.
Uses
Used in Pharmaceutical Industry:
BIS(2-THIENYL) KETONE is used as a key intermediate in the synthesis of antitumor agents, specifically for the formation of hydantoins. These hydantoins are crucial in the development of cancer treatments, targeting and inhibiting the growth of tumor cells.
Additionally, BIS(2-THIENYL) KETONE is used as an impurity in the synthesis of Tiotropium Bromide (T444850), a muscarinic receptor antagonist. Tiotropium Bromide serves as a bronchodilator, helping to relax and widen the airways in patients with respiratory conditions such as chronic obstructive pulmonary disease (COPD) and asthma. The presence of BIS(2-THIENYL) KETONE in this synthesis process highlights its importance in the development of medications that improve lung function and overall respiratory health.
Check Digit Verification of cas no
The CAS Registry Mumber 704-38-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,0 and 4 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 704-38:
(5*7)+(4*0)+(3*4)+(2*3)+(1*8)=61
61 % 10 = 1
So 704-38-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H6OS2/c10-9(7-3-1-5-11-7)8-4-2-6-12-8/h1-6H
704-38-1Relevant articles and documents
Co(III)-Catalyzed Synthesis of Quinazolines via C-H Activation of N-Sulfinylimines and Benzimidates
Wang, Fen,Wang, He,Wang, Qiang,Yu, Songjie,Li, Xingwei
supporting information, p. 1306 - 1309 (2016/04/01)
C-H activation of arenes has been established as an important strategy for heterocycle synthesis via annulations between arenes and unsaturated coupling partners. However, nitriles failed to act as such a coupling partner. Dioxazolones have been employed as a synthon of nitriles, and subsequent coupling with arenes such as N-sulfinylimines and benzimidates bearing a functionalizable directing group provided facile access to two classes of quinazolines under Co(III)-catalysis.
A Direct Access to α-Diones from Oxalyl Chloride
Babudri, Francesco,Fiandanese, Vito,Marchese, Giuseppe,Punzi, Angela
, p. 7305 - 7308 (2007/10/02)
Cross-coupling reactions of oxalyl chloride with organocopper reagents, derived from Grignard reagents, cuprous bromide, and lithium bromide, provide a simple and straightforward method for the synthesis of symmetrical α-diones in very good yields.