70452-32-3

Basic information

• Product Name: 5-nitro-3-(2-oxo-2-phenylethylidene)-1,3-dihydro-2H-indol-2-one
• CAS NO: 70452-32-3
• Molecular Formula: C₁₆H₁₀N₂O₄
• Molecular Weight: 294.2616
• Mol File: 70452-32-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 546.4°C at 760 mmHg
• Flash Point: 284.2°C
• Density: 1.474g/cm³
• Vapor Pressure: 5.42E-12mmHg at 25°C
• Refractive Index: 1.73
• CAS DataBase Reference: 5-nitro-3-(2-oxo-2-phenylethylidene)-1,3-dihydro-2H-indol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-nitro-3-(2-oxo-2-phenylethylidene)-1,3-dihydro-2H-indol-2-one(70452-32-3)
• EPA Substance Registry System: 5-nitro-3-(2-oxo-2-phenylethylidene)-1,3-dihydro-2H-indol-2-one(70452-32-3)

Safety Data

• Hazardous Substances Data: 70452-32-3(Hazardous Substances Data)

Usage

General Description

5-nitro-3-(2-oxo-2-phenylethylidene)-1,3-dihydro-2H-indol-2-one is a chemical compound with a complex structure. It belongs to the class of nitro compounds and contains a nitro group along with a 2-oxo-2-phenylethylidene group attached to a 1,3-dihydro-2H-indol-2-one ring system. 5-nitro-3-(2-oxo-2-phenylethylidene)-1,3-dihydro-2H-indol-2-one may have various potential applications in organic synthesis, medicinal chemistry, or material science due to its unique structure and functional groups. Further studies and research are needed to explore its potential uses and properties.

Upstream product

• 611-09-6 5-nitroisatin 
• 98-86-2 acetophenone 
• 20913-05-7 (Benzoylmethylene)triphenylphosphorane 

Relevant articles and documents

Phosphine-Catalyzed Interrupted Morita–Baylis–Hillman Reaction and Switchable Domino Reactions of α-Substituted Activated Olefins with Formaldehyde and Mechanism Elucidation

3-Olefinic oxindoles can undergo interrupted Morita-Baylis-Hillman reaction with formaldehyde. Apart from the previous reported dephosphoration to access reductive aldol-type products, here we uncovered that completely different pathways were followed by tuning the substitutions of 3-olefinic oxindoles. In combination with formalin, an unexpected domino phosphorus-ylide formation, aldol-type addition, hemeacetal formation and O-substitution process was observed to produce 1,3-dioxolane derivatives. Moreover, a switchable sequence to produce formate derivatives via a key hydride transfer process was furnished by simply replacing formalin with paraformaldehyde. Density functional theory calculations were conducted to well elucidate the catalytic reaction mechanism.

Synthesis of 3-hydroxy-3-phenacyloxindole analogs

-