705-83-9

Basic information

• Product Name: 3-(3-fluorophenyl)propiolic acid
• Synonyms: 3-(3-fluorophenyl)propiolic acid;3-(3-FLUOROPHENYL)PROP-2-YNOIC ACID;(3-Fluoro-phenyl)-propynoic acid
• CAS NO: 705-83-9
• Molecular Formula: C₉H₅FO₂
• Molecular Weight: 164.1332032
• Mol File: 705-83-9.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(3-fluorophenyl)propiolic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-fluorophenyl)propiolic acid(705-83-9)
• EPA Substance Registry System: 3-(3-fluorophenyl)propiolic acid(705-83-9)

Safety Data

• Hazardous Substances Data: 705-83-9(Hazardous Substances Data)

Usage

Description

3-(3-fluorophenyl)propiolic acid is a chemical compound with the molecular formula C9H6F2O2. It is a derivative of propiolic acid, containing a 3-fluorophenyl group. 3-(3-fluorophenyl)propiolic acid is characterized by its unique chemical structure and properties, which include specific reactivity due to the presence of the fluorine atom in the phenyl ring.

Uses

Used in Organic Synthesis:
3-(3-fluorophenyl)propiolic acid is used as a building block in organic synthesis for the creation of various complex organic molecules. Its ability to undergo nucleophilic addition and substitution reactions makes it a versatile component in the synthesis of new compounds.
Used in Pharmaceutical Development:
In the Pharmaceutical Industry, 3-(3-fluorophenyl)propiolic acid is used as a key intermediate in the development of new drugs. Its unique chemical structure and properties contribute to the design and synthesis of potential therapeutic agents, particularly in medicinal chemistry and drug discovery.
Used in Material Science:
3-(3-fluorophenyl)propiolic acid may also find applications in the field of material science. The specific reactivity and properties conferred by the fluorine atom in the phenyl ring can be harnessed to develop new materials with tailored characteristics for various applications.

Upstream product

• 124-38-9 carbon dioxide 
• 2561-17-3 1-ethynyl-3-fluoro-benzene 
• 1121-86-4 1-Fluoro-3-iodobenzene 
• 471-25-0 Propiolic acid 
• 221148-38-5 methyl 3-(3-fluorophenyl)prop-2-ynoate 

Downstream Products

• 52112-24-0 1-fluoro-3-(prop-1-yn-1-yl)benzene 
• 406687-60-3 {[3-(3-fluoro-phenyl)-propynoyl]-methyl-amino}-acetic acid ethyl ester 
• 849150-02-3 3-(3-fluoro-phenyl)-1-methyl-5-oxo-2,5-dihydro-1H-pyrrole-2-carboxylic acid ethyl ester 
• 1431960-65-4 C₁₆H₁₉FN₂O₃ 
• 1431960-66-5 C₁₁H₁₁FN₂O 
• 1431959-41-9 N-(2-(3-((1H-pyrrolo[2,3-b]pyridin-4-yl)methyl)thioureido)ethyl)-3-(3-fluorophenyl)propiolamide trifluoroacetate 
• 633327-36-3 (E)-2-(3-fluorostyryl)-4,4,5,5-tetramethyl-1,3-dioxa-2-borolane 
• 1174916-26-7 diethyl ((3-fluorophenyl)ethynyl)phosphonate 

Relevant articles and documents

N-Heterocyclic carbene-nitrogen molybdenum catalysts for utilization of CO2

Three new N-heterocyclic carbene-nitrogen molybdenum complex was synthesized, and its catalytic activity was evaluated in the cycloaddition of epoxides with CO2. The molybdenum complex combined with tetrabutyl ammonium iodide (TBAI) resulted in a catalytic system for efficient conversion of a wide range of terminal and internal epoxides under 80 °C and 5–7 bar pressure for CO2. The cooperative catalysis mechanism between molybdenum complex and TBAI was elucidated, in which molybdenum complex was used as Lewis acid, and TBAI was employed as nucleophilic reagent. In addition, the NHC-Mo catalytic system was also successfully applied for the direct carboxylation of terminal alkynes with CO2.

Microwave-assisted fabrication of a mixed-ligand [Cu4(μ3-OH)2]-cluster-based metal–organic framework with coordinatively unsaturated metal sites for carboxylation of terminal alkynes with carbon dioxide

The development of efficient and stable metal–organic framework (MOF) catalysts with coordinatively unsaturated metal sites for modern organic synthesis is greatly important. Herein, a robust [Cu4(μ3-OH)2]-cluster-based MOF (Cu-MOF) with a mixed-ligand system was successfully fabricated by a microwave-assisted method under mild conditions. The as-prepared Cu-MOF catalyst possessing unsaturated Cu (II) sites exhibited excellent catalytic activity toward the direct carboxylation of 1-ethynylbenzene with CO2, and various propiolic acid derivatives were synthesized in moderate to good yields under optimized reaction conditions. Furthermore, the catalyst remained stable and could be easily recycled for five sequential runs without incredible decrease in catalytic efficiency.

Oxidant- and additive-free simple synthesis of 1,1,2-triiodostyrenes by one-pot decaroboxylative iodination of propiolic acids

A metal- and oxidant-free facile synthesis of a range of 1,1,2-triiodostryrene derivatives has been developed which utilizes a simple decarboxylative triiodination of propiolic acids using molecular iodine and sodium acetate in a one-pot manner. Electron-