70502-03-3

Basic information

• Product Name: (5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)METHANOL
• Synonyms: (5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)METHANOL;(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methanol 97%;4-(Hydroxymethyl)-5-methyl-2-phenyl-1,3-oxazole 97%
• CAS NO: 70502-03-3
• Molecular Formula: C₁₁H₁₁NO₂
• Molecular Weight: 189.21
• Mol File: 70502-03-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 117 °C
• Boiling Point: 361.125°C at 760 mmHg
• Flash Point: 172.202°C
• Appearance: /
• Density: 1.176g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: (5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)METHANOL(70502-03-3)
• EPA Substance Registry System: (5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)METHANOL(70502-03-3)

Safety Data

• Hazardous Substances Data: 70502-03-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H11NO2/c1-8-10(7-13)12-11(14-8)9-5-3-2-4-6-9/h2-6,13H,7H2,1H3

Upstream product

• 70501-99-4 5-methyl-4-methylene-2-phenyl-4,5-dihydro-oxazole 
• 61151-96-0 ethyl 5-methyl-2-phenyloxazole-4-carboxylate 
• 70501-97-2 benzimidic acid 1-methyl-prop-2-ynyl ester 

Downstream Products

• 70170-23-9 5-methyl-2-phenyl-1,3-oxazole-4-carboxaldehyde 
• 178610-63-4 4-(2-fluoro-4-nitrophenoxymethyl)-5-methyl-2-phenyloxazole 
• 157169-73-8 2-(5-methyl-2-phenyl-4-oxazolylmethoxy)-5-nitropyridine 
• 923017-15-6 [2-(benzyloxy)-4-methoxyphenyl]{6-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]pyridin-3-yl}methanone 
• 157169-74-9 5-amino-2-(5-methyl-2-phenyl-4-oxazolylmethoxy)pyridine 
• 159017-79-5 (E)-3-[6-(5-methyl-2-phenyl-4-oxazolylmethoxy)-3-pyridyl]acrylaldehyde 
• 178610-64-5 3-fluoro-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)aniline 
• 166253-88-9 methyl (E)-3-[6-(5-methyl-2-phenyl-4-oxazolylmethoxy)-3-pyridyl]acrylate 
• 178238-83-0 (E)-[3-fluoro-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)]cinnamaldehyde 
• 166253-89-0 (E)-3-[6-(5-methyl-2-phenyl-4-oxazolylmethoxy)-3-pyridyl]-2-propen-1-ol 
• 166253-87-8 methyl 2-bromo-3-[6-(5-methyl-2-phenyl-4-oxazolylmethoxy)-3-pyridyl]propionate 
• 166254-17-7 2-(5-methyl-2-phenyl-oxazol-4-ylmethoxy)-5-[3-(1H-tetrazol-5-yl)-propyl]-pyridine 
• 132451-29-7 N-methyl-N-[(5-methyl-2-phenyl-4-oxazolyl)-methyl]amine 
• 132451-31-1 4-methylaminocarbonyl>benzaldehyde 

Relevant articles and documents

NOVEL COMPOUNDS AS AGONIST FOR PPAR GAMMA AND PPAR ALPHA, METHOD FOR PREPARATION OF THE SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME

The present invention relates to novel compounds accelerating the activity of Peroxisome proliferator-activated receptor gamma (PPARγ) and alpha (PPARα), processes of preparing the same, and pharmaceutical compositions containing the same as an active agent.

Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis

The subject invention provides pharmaceutical compounds useful in the treatment of Type II diabetes. These compounds are advantageous because they are readily metabolized by the metabolic drug detoxification systems. Particularly, thiazolidinedione analogs that have been designed to include esters within the structure of the compounds are provided. This invention is also drawn to methods of treating disorders, such as diabetes, comprising the administration of therapeutically effective compositions comprising compounds that have been designed to be metabolized by serum or intracellular hydrolases and esterases. Pharmaceutical compositions of the ester-containing thiazolidinedione analogs are also taught.

Substituted oxazoles and thiazoles derivatives as hPPARγ and hPPARα activators

The present invention discloses compounds of formula (I), and tautomeric forms, pharmaceutically acceptable salts, or solvates thereof. Preferably, the compounds of the invention are dual activators of hPPARγ and hPPAR{acute over (α)}.