70684-82-1 Usage
Description
Methyl 1,2,3,6-Tetrahydropyridine-4-carboxylate Hydrochloride is an organic compound that serves as a key intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its unique structure and properties, making it a valuable component in the development of new drugs and therapies.
Uses
Used in Pharmaceutical Industry:
Methyl 1,2,3,6-Tetrahydropyridine-4-carboxylate Hydrochloride is used as a synthetic intermediate for the production of 1,2,3,6-Tetrahydro-4-pyridinemethanol (T295540) and a methyl ester of Isoguvacine Hydrochloride (I819560). These compounds have potential applications in the development of new drugs and therapies.
Used in Prodrug Synthesis:
Methyl 1,2,3,6-Tetrahydropyridine-4-carboxylate Hydrochloride is used to synthesize esters of isoguvacine that are potential prodrugs with weak anticonvulsant activities. This makes it a valuable component in the development of new treatments for epilepsy and other neurological disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 70684-82-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,6,8 and 4 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 70684-82:
(7*7)+(6*0)+(5*6)+(4*8)+(3*4)+(2*8)+(1*2)=141
141 % 10 = 1
So 70684-82-1 is a valid CAS Registry Number.
70684-82-1Relevant articles and documents
Esters of Isoguvacine as Potential Prodrugs
Falch, Erik,Krogsgaard-Larsen, Povl
, p. 285 - 289 (1981)
The syntheses of the methyl ester, butyl ester, (ethoxycarbonyl)methyl ester, and 11 (acyloxy)methyl esters of the potent γ-aminobutyric acid agonist isoguvacine (1,2,3,6-tetrahydropyridine-4-carboxylic acid) are described.The chemical stability of the esters and their in vitro rates of hydrolysis under approximately physiological conditions by nonspecific esterases from human serum were examined.A selected number of the esters were tested for antagonism of convulsions induced by bicuculline, isoniazide, and by electroshock.While the compounds showed only weak activities in the bicuculline and isoniazide tests, a good correlation between in vitro rates of enzymatic hydrolysis and the time of onset of the antagonism of the electroshock-induced convulsions could be found.
