707-60-8

Basic information

• Product Name: 4-BROMO-N,N-DIMETHYLBENZENESULFONAMIDE
• Synonyms: p-bromo-n,n-dimethyl-benzenesulfonamid;N,N-DIMETHYL 4-BROMOBENZENESULFONAMIDE;4-BROMO-N,N-DIMETHYLBENZENESULFONAMIDE;4-BROMO-N,N-DIMETHYLBENZENESULPHONAMIDE;4-BROMOBENZENEDIMETHYLSULFONAMIDE;4-Bromo-N,N-dimethylbenzenesulphonamide 97%;4-broMo-N,N-diMethylbenzene-1-sulfonaMide;BenzenesulfonaMide, 4-broMo-N,N-diMethyl-
• CAS NO: 707-60-8
• Molecular Formula: C₈H₁₀BrNO₂S
• Molecular Weight: 264.14
• Product Categories: blocks;Bromides;Sulfonamides;Aryl;Halogenated;Organohalides;alkyl bromide
• Mol File: 707-60-8.mol
• Article Data: 20

Chemical Properties

• Melting Point: 88-90
• Boiling Point: 329 °C at 760 mmHg
• Flash Point: 152.8 °C
• Appearance: /
• Density: 1.543 g/cm³
• PKA: -5.11±0.70(Predicted)
• CAS DataBase Reference: 4-BROMO-N,N-DIMETHYLBENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-N,N-DIMETHYLBENZENESULFONAMIDE(707-60-8)
• EPA Substance Registry System: 4-BROMO-N,N-DIMETHYLBENZENESULFONAMIDE(707-60-8)

Safety Data

• Hazard Codes: Xi
• RTECS: DB0700000
• HazardClass: IRRITANT
• Hazardous Substances Data: 707-60-8(Hazardous Substances Data)

Usage

General Description

4-Bromo-N,N-dimethylbenzenesulfonamide is a chemical compound with the formula C8H10BrNO2S. It is a sulfonamide derivative used as a reagent in organic synthesis and pharmaceutical industry. The compound has a bromine substituent attached to the benzene ring, as well as two methyl groups and a sulfonamide functional group. It is commonly used as a building block in the production of various pharmaceuticals and agrochemicals. The compound has also been studied for its potential antimicrobial and anticancer activities. Overall, 4-Bromo-N,N-dimethylbenzenesulfonamide plays an important role as a versatile building block in the synthesis of various bioactive compounds.

InChI:InChI=1/C8H10BrNO2S/c1-10(2)13(11,12)8-5-3-7(9)4-6-8/h3-6H,1-2H3

Upstream product

• 108-86-1 bromobenzene 
• 124-40-3 dimethyl amine 
• 98-58-8 4-bromobenzenesulfonyl chloride 
• 106-53-6 para-bromobenzenethiol 
• 68-12-2 N,N-dimethyl-formamide 
• 1709-59-7 4-amino-N,N-dimethylbenzenesulphonamide 
• 34176-08-4 sodium 4-bromobenzenesulfinate 
• 110-18-9 N,N,N,N,-tetramethylethylenediamine 
• 87-52-5 3-(Dimethylaminomethyl)indole 
• 701-34-8 4-bromo-benzenesulfonic acid amide 
• 77-78-1 dimethyl sulfate 
• 103-83-3 N,N'-dimethylbenzylamine 

Downstream Products

• 16185-23-2 4-(2-Hydroxymethyl-phenylsulfanyl)-N,N-dimethyl-benzenesulfonamide 
• 16185-22-1 N,N-Dimethyl-4-brombenzolsulfamid 
• 16185-24-3 4-(2-Chloromethyl-phenylsulfanyl)-N,N-dimethyl-benzenesulfonamide 
• 16185-25-4 4-(2-Cyanomethyl-phenylsulfanyl)-N,N-dimethyl-benzenesulfonamide 
• 16185-26-5 [2-(4-Dimethylsulfamoyl-phenylsulfanyl)-phenyl]-acetic acid 
• 486422-04-2 N,N-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene-1-sulfonamide 
• 1072106-57-0 C₂₁H₂₀N₄O₂S 
• 1227370-69-5 4-(2-formyl-phenylethynyl)-N,N-dimethyl-benzenesulfonamide 
• 1253575-22-2 (4-(N,N-dimethylsulfamoyl)phenyl)magnesium bromide 
• 1253575-20-0 4-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-(6-methoxypyridin-3-ylamino)pyridin-3-yl)(hydroxy)methyl)-N,N-dimethylbenzenesulfonamide 
• 1253575-19-7 2-((5-(4-(bis(4-methoxybenzyl)amino)-6-methyl-1,3,5-triazin-2-yl)-6-(6-methoxypyridin-3-ylamino)pyridin-3-yl)(hydroxy)methyl)-4-bromo-N,N-dimethylbenzenesulfonamide 
• 1303576-89-7 methyl 6-(4-(N,N-dimethylsulfamoyl)phenyl)-1-hydroxy-1H-indole-2-carboxylate 
• 1303572-01-1 6-(4-(N,N-dimethylsulfamoyl)phenyl)-1-hydroxy-1H-indole-2-carboxylic acid 
• 1462903-77-0 N,N-dimethyl 4-(pyridin-3-yl)benzenesulfonamide 

Relevant articles and documents

Debenzylative Sulfonylation of Tertiary Benzylamines Promoted by Visible Light

An efficient, general, inexpensive, and environmentally friendly photosynthesis of sulfonamides via visible light promoted debenzylative sulfonylation of tertiary benzylamines is described. Compared to the traditional S?N coupling reactions, which are promoted by oxidative C?N bond cleavage of symmetrical tertiary alkylamines, this strategy provides a selective C?N bond cleavage protocol and avoids the use of transition-metal, explosive oxidants, and ligands.

N-Substituted Nipecotic Acids as (S)-SNAP-5114 Analogues with Modified Lipophilic Domains

Potential mGAT4 inhibitors derived from the lead substance (S)-SNAP-5114 have been synthesized and characterized for their inhibitory potency. Variations from the parent compound included the substitution of one of its aromatic 4-methoxy and 4-methoxyphenyl groups, respectively, with a more polar moiety, including a carboxylic acid, alcohol, nitrile, carboxamide, sulfonamide, aldehyde or ketone function, or amino acid partial structures. Furthermore, it was investigated how the substitution of more than one of the aromatic 4-methoxy groups affects the potency and selectivity of the resulting compounds. Among the synthesized test substances (S)-1-{2-[(4-formylphenyl)bis(4-methoxyphenyl)-methoxy]ethyl}piperidine-3-carboxylic acid, that features a carbaldehyde function in place of one of the aromatic 4-methoxy moieties of (S)-SNAP-5114, was found to have a pIC50 value of 5.89±0.07, hence constituting a slightly more potent mGAT4 inhibitor than the parent substance while showing comparable subtype selectivity.

HALOALLYLAMINE SULFONE DERIVATIVE INHIBITORS OF LYSYL OXIDASES AND USES THEREOF

The present invention relates to novel compounds which are capable of inhibiting certain amine oxidase enzymes. These compounds are useful for treatment of a variety of indications, e.g., fibrosis, cancer and/or angiogenesis in human subjects as well as i