70705-33-8

Basic information

• Product Name: 7-METHYL-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: ETHYL 7-METHYLIMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLATE;7-METHYL-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER;methyl 7-methylimidazo[1,2-a]pyridine-2-carboxylate
• CAS NO: 70705-33-8
• Molecular Formula: C₁₁H₁₂N₂O₂
• Molecular Weight: 204.23
• Product Categories: blocks;Carboxes;Pyridines;Heterocycle-Pyridine series
• Mol File: 70705-33-8.mol
• Article Data: 7

Chemical Properties

• Melting Point: 126-129°
• Appearance: /
• Density: 1.2 g/cm³
• Refractive Index: 1.585
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.92±0.50(Predicted)
• CAS DataBase Reference: 7-METHYL-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHYL-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER(70705-33-8)
• EPA Substance Registry System: 7-METHYL-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER(70705-33-8)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 70705-33-8(Hazardous Substances Data)

Usage

General Description

7-Methyl-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester is a chemical compound characterized by its role as a building block in pharmaceutical research and development. It is classified under heterocyclic compounds (compounds containing rings made of more than one kind of atom - in this case, nitrogen and carbon), and it is particularly known for its imidazopyridine scaffold which is frequently utilized in various drug designs. As an ethyl ester, it also possesses properties useful in increasing a compound's lipophilicity, thereby aiding in bioavailability. Common applications of this chemical compound are typically research-based and further exploration is ongoing to discover potential therapeutic applications.

InChI:InChI=1/C11H12N2O2/c1-3-15-11(14)9-7-13-5-4-8(2)6-10(13)12-9/h4-7H,3H2,1-2H3

Upstream product

• 695-34-1 2-Amino-4-methylpyridine 
• 70-23-5 ethyl Bromopyruvate 

Downstream Products

• 859788-65-1 3-(2-ethoxy-phenyl)-7-methyl-2H-2,4,4b,9-tetraaza-fluoren-1-one 
• 859788-40-2 3-(2-ethoxy-benzoylamino)-7-methyl-imidazo[1,2-a]pyridine-2-carboxylic acid amide 
• 155539-86-9 ethyl 7-methyl-3-phenylimidazo[1,2-a]pyridine-2-carboxylate 
• 1276681-18-5 7-dibromomethyl-3-phenylimidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester 
• 1276681-19-6 7-formyl-3-phenylimidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester 
• 1276681-21-0 3-(4-fluorophenyl)-7-methylimidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester 
• 1276681-22-1 7-bromomethyl-3-(4-fluorophenyl)imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester 

Relevant articles and documents

Microwave-Assisted Suzuki–Miyaura and Sonogashira Coupling of 4-Chloro-2-(trifluoromethyl)pyrido[1,2-e]purine Derivatives

The convenient preparation of three imidazo[1,2-a]pyridine-2-carboxamide intermediates is reported through known Strecker–Ugi type multicomponent reactions, Tschitschibabin type condensations, and further synthetic sequences. The derivatives were then efficiently converted to novel 4-chloro-2-(trifluoromethyl)pyrido[1,2-e]purines by their original reactions with 2,2,2-trifluoroacetamide, followed by subsequent dehydroxychlorination reactions. These compounds were cross-coupled under microwave irradiation through SuzukiMiyaura and Sonogashira palladium(0) catalysis to various aromatic and alkynyl reagents, thus providing the related C-4 substituted pyrido[1,2-e]purines of biological interest in good yields.

Discovery of imidazopyridine derivatives as highly potent respiratory syncytial virus fusion inhibitors

A series of imidazolepyridine derivatives were designed and synthesized according to the established docking studies. The imidazopyridine derivatives were found to have good potency and physical-chemical properties. Several highly potent compounds such as 8ji, 8jl, and 8jm were identified with single nanomolar activities. The most potent compound 8jm showed an IC50 of 3 nM, lower microsome clearance and no CYP inhibition. The profile of 8jm appeared to be superior to BMS433771, and supported further optimization.

INDOLIZINE INHIBITORS OF 5-LIPOXYGENASE

Described herein are compounds and pharmaceutical compositions containing such compounds, which inhibit the activity of 5-lipoxygenase (5-LO). Also described herein are methods of using such 5-LO inhibitors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other leukotriene-dependent or leukotriene mediated conditions, diseases, or disorders.