70782-12-6

Basic information

• Product Name: N-Cbz-diethanolamine
• Synonyms: N-Cbz-diethanolamine;Carbamic acid, N,N-bis(2-hydroxyethyl)-phenylmethyl ester;BENZYL BIS(2-HYDROXYETHYL)CARBAMATE
• CAS NO: 70782-12-6
• Molecular Formula: C₁₂H₁₇NO₄
• Molecular Weight: 239.26768
• Mol File: 70782-12-6.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 417.6±45.0 °C(Predicted)
• Appearance: /
• Density: 1.233±0.06 g/cm3(Predicted)
• PKA: 14.28±0.10(Predicted)
• CAS DataBase Reference: N-Cbz-diethanolamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Cbz-diethanolamine(70782-12-6)
• EPA Substance Registry System: N-Cbz-diethanolamine(70782-12-6)

Safety Data

• Hazardous Substances Data: 70782-12-6(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 111-42-2 2,2'-iminobis[ethanol] 
• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 

Downstream Products

• 194225-83-7 N-(carbobenzyloxy)diethanolamine tert-butyldiphenylsilyl ether 
• 133024-90-5 N-benzyloxycarbonyldiethanolamine dimesylate 
• 374805-45-5 N-benzyloxycarbonylmonoazatrithia-12-crown-4 
• 680569-99-7 (2-bromo-ethyl)-(2-triisopropylsilanyloxy-ethyl)-carbamic acid benzyl ester 
• 189323-09-9 benzyl bis(2-bromoethyl)carbamate 
• 1357575-41-7 benzyl bis(2-(di-tert-butoxyphosphoryloxy)ethyl)carbamate 
• 1417632-78-0 C₃₁H₃₁NO₄ 
• 25070-74-0 1-benzyloxycarbonylpyrrolidine 
• 951744-84-6 1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)oxazol-2-yl)-4-hydroxymethylpiperidine 
• 951744-37-9 methyl 1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)oxazol-2-yl)-4-piperidinecarboxylate 
• 951744-85-7 4-acetoxymethyl-1-benzyloxycarbonyl-4-(4,5-bis(4-methoxyphenyl)oxazol-2-yl)piperidine 
• 516462-74-1 O-(4,4'-dimethoxytrityl)diethanolamine 

Relevant articles and documents

Synthesis of constrained tetracyclic peptides by consecutive CEPS, CLIPS, and oxime ligation

In Nature, multicyclic peptides constitute a versatile molecule class with various biological functions. For their pharmaceutical exploitation, chemical methodologies that enable selective consecutive macrocyclizations are required. We disclose a combination of enzymatic macrocyclization, CLIPS alkylation, and oxime ligation to prepare tetracyclic peptides. Five new small molecular scaffolds and differently sized model peptides featuring noncanonical amino acids were synthesized. Enzymatic macrocyclization, followed by one-pot scaffold-assisted cyclizations, yielded 21 tetracyclic peptides in a facile and robust manner.

NEW COMPOUNDS

There is provided compounds of formula I,wherein R1 R2, X, R3, X1, X2, Xa, Xb, Xc, Xd, Xf, X9 and R4 have meanings given in the description (and which compounds are optionally substituted as indicated in the description), and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PIM family kinase, such as PIM-1, PIM-2 and/or PIM-3) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease. There is also provided combinations comprising the compounds of formula I.

Amberlyst-15 catalyzed Cbz protection of amines under solvent-free conditions

Amberlyst-15 can effectively catalyze Cbz protection of aliphatic and aromatic amines within 10-15 min under solvent-free conditions. The catalyst can be used repeatedly without loss of activity, and the reaction requires no workup and gives excellent yields. Taylor & Francis Group, LLC.