7081-44-9 Usage
Description
Cloxacillin sodium is a semi-synthetic antibiotic derived from the penicillin group, specifically designed to resist the action of beta-lactamase enzymes. It is effective against a range of bacterial infections and is known for its broad-spectrum activity.
Uses
Used in Pharmaceutical Industry:
Cloxacillin sodium is used as an antibiotic for treating various bacterial infections, particularly those caused by Gram-positive bacteria, including -lactamase producing Staphylococci. Its effectiveness against these bacteria makes it a valuable addition to the arsenal of antibiotics used in the medical field.
Used in Clinical Settings:
Cloxacillin sodium is used as a therapeutic agent for patients suffering from bacterial infections that are resistant to other penicillins due to the presence of beta-lactamase enzymes. Its ability to target and combat these infections makes it a crucial component in the treatment of various illnesses.
Brand Names in the US:
Some of the brand names under which Cloxacillin sodium is marketed in the United States include Cloxapen, Orbenin, and Tegopen. These brand names help to identify the specific formulations and preparations of the antibiotic, allowing healthcare professionals and patients to select the most appropriate treatment option.
Clinical Use
The chlorine atom ortho to the position of attachment of thephenyl ring to the isoxazole ring enhances the activity ofcloxacillin sodium, [3-(o-chlorophenyl)-5-methyl-4-isoxazolyl]penicillin sodium monohydrate (Tegopen), over that ofoxacillin, not by increasing its intrinsic antibacterial activitybut by enhancing its oral absorption, leading to higher plasmalevels. In almost all other respects, it resembles oxacillin.
Safety Profile
Moderately toxic by intraperitoneal, intramuscular, subcutaneous, and intravenous routes. Mildly toxic by ingestion. When heated to decomposition it emits very toxic fumes of Cl-, NOx, Na2O, and SOx.
Veterinary Drugs and Treatments
Cloxacillin is used via intramammary infusion in dry and lactating
dairy cattle.
Check Digit Verification of cas no
The CAS Registry Mumber 7081-44-9 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,0,8 and 1 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 7081-44:
(6*7)+(5*0)+(4*8)+(3*1)+(2*4)+(1*4)=89
89 % 10 = 9
So 7081-44-9 is a valid CAS Registry Number.
InChI:InChI=1/C19H18ClN3O5S.Na.H2O/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23;;/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27);;1H2/t13-,14+,17-;;/m1../s1
7081-44-9Relevant articles and documents
Manufacture of semi-synthetic penicillin antibiotics
-
, (2008/06/13)
Improvements in or relating to the manufacture of semi-synthetic penicillin antibiotics are described. More particularly an improved process for the preparation of a 6β-acylamino penicillanic acid antibiotic product is described in which 6β-aminopenicillanic acid (6-APA) is reacted in an inert solvent with a silylating agent to form a silylated compound of formula (I) STR1 wherein R1 represents a hydrogen atom or a tri(C1-6 alkyl)silyl group, and R2 represents a tri(C1-6 alkyl)silyl group and the compound of formula (I) is thereafter contacted with an acyl chloride or protected acyl chloride corresponding to the desired 6β-acylamino group, the silyl groups are cleaved and the desired antibiotic product is recovered, silylation being effected using a tri(C1-6 alkyl) silylurea or tri(C1-6 alkyl) halosilane and the compound of formula (I) produced being reacted without intermediate isolation with the acyl chloride or protected acyl chloride, wherein acylation is effected in the presence of a hydrogen halide acceptor mixture comprising in excess of 0.15 and preferably up to 3.00 moles of urea per mole of 6-APA; in excess of 0.15, and preferably up to 1.30 moles of bis-tri-(C1-6 alkyl)silylurea per mole of 6-APA; and in excess of 0.25, and preferably up to 3.30 moles of tri-(C1-6 alkyl)-ammonium halide per mole of 6-APA. The process is especially useful for the preparation of ampicillin and amoxycillin in high yield and high purity.
Pharmaceutical formulations
-
, (2008/06/13)
Microcapsules which have an average diameter of from 100μ to 300μ and which comprise 94% to 99.9% of a medicament coated by 0.1% to 6% of a coating agent may be formed into a powder with 0% to 95% excipients or a tablet or capsule with a carrier.