7081-53-0 Usage
Description
Doxapram is a central respiratory stimulant. It increases respiration and phrenic nerve activity in anesthetized cats at a dose of 1.0 mg/kg. Doxapram acts through carotid chemoreceptors, lacking activity in anesthetized cats following carotid denervation. Formulations containing doxapram have been used to increase respiration in patients with chronic pulmonary disease, respiratory depression induced by drug overdose, and to stimulate deep breathing post-anesthesia.
Chemical Properties
White or almost white, crystalline powder.
Uses
antibacterial
Definition
ChEBI: The monohydrate form of doxapram hydrochloride. A central and respiratory stimulant with a brief duration of action, it is used as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease,
nd of postoperative respiratory depression. It has also been used for treatment of postoperative shivering.
Brand name
Dopram (Baxter Healthcare).
General Description
Doxapram, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone hydrochloride hydrate (Dopram), has an obscuremolecular mechanism of action. Overall, it stimulatesrespiration by action on peripheral carotid chemoreceptors.It has use as a respiratory stimulant postanesthetically, afterCNS depressant drug overdose, in chronic obstructive pulmonarydiseases, and in the apneas. Dopram is administeredexclusively by intravenous injection. Because of the benzylalcohol content of the injectable formulation, Dopram mustnever be given to neonates.
Clinical Use
Postoperative respiratory depressionAcute respiratory failure
Drug interactions
Potentially hazardous interactions with other drugsAnaesthetics: increased risk of arrhythmias with
volatile liquid general anaesthetics - avoid for at least
10 minutes after volatile liquid general anaesthetics.
Metabolism
Doxapram is extensively metabolised in the liver, and
the major route of excretion of metabolites and a small
amount of unchanged drug is thought to be via bile to the
faeces.
Check Digit Verification of cas no
The CAS Registry Mumber 7081-53-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,0,8 and 1 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 7081-53:
(6*7)+(5*0)+(4*8)+(3*1)+(2*5)+(1*3)=90
90 % 10 = 0
So 7081-53-0 is a valid CAS Registry Number.
InChI:InChI=1/C24H30N2O2.ClH.H2O/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21;;/h3-12,22H,2,13-19H2,1H3;1H;1H2
