70845-73-7

Basic information

• Product Name: Benzoic acid, 3-methoxy-4,5-bis(phenylmethoxy)-
• CAS NO: 70845-73-7
• Molecular Formula: C22H20O5
• Molecular Weight: 364.398
• Mol File: 70845-73-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 3-methoxy-4,5-bis(phenylmethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 3-methoxy-4,5-bis(phenylmethoxy)-(70845-73-7)
• EPA Substance Registry System: Benzoic acid, 3-methoxy-4,5-bis(phenylmethoxy)-(70845-73-7)

Safety Data

• Hazardous Substances Data: 70845-73-7(Hazardous Substances Data)

Upstream product

• 3934-86-9 methyl 3,4-dihydroxy-5-methoxybenzoate 
• 100-44-7 benzyl chloride 
• 70845-72-6 methyl 4,5-bisbenzyloxy-3-methoxybenzoate 
• 99-24-1 methyl galloate 
• 149-91-7 3,4,5-trihydroxybenzoic acid 

Downstream Products

• 83813-99-4 3,4-dibenzyloxy-5-methoxybenzoic anhydride 
• 1190414-53-9 (2R,3S)-5,7-bis(benzyloxy)-2-[3,4-bis(benzyloxy)phenyl]-3,4-dihydro-2H-1-benzopyran-3-yl 3,4-bis(benzyloxy)-5-methoxybenzoate 
• 83814-01-1 5,7-dihydroxy-3',4'-dibenzyloxy-3,5'-dimethoxyflavone 
• 73607-03-1 5,7,3',4'-tetrahydroxy-3,5'-dimethoxyflavone 
• 70845-74-8 3,4-bis(benzyloxy)-5-methoxybenzoyl chloride 
• 246048-05-5 benzyl (S)-2-(5-(dimethylamino)naphthalene-1-sulfonamidyl)-3-((3,4-bis(benzyloxy)-5-methoxybenzoyl)oxy)propionate 
• 83104-87-4 epigallocatechin (3-O-methyl)gallate 
• 83104-86-3 (2R,3R)-3,4-dihydro-5,7-dihydroxy-2-(3,4-dihydroxyphenyl)-2H-1-benzopyran-3-yl 3,4-dihydroxy-5-methoxybenzoate 
• 901125-31-3 (-)-(2R,3R)-cis-5,7-bis(benzyloxy)-2-[3',4',5'-tris(benzyloxy)-phenyl]chroman-3-yl 3'',4''-dibenzyloxy-5''-methoxybenzoate 
• 901125-28-8 (2R,3R)-5,7-bis(benzyloxy)-2-[3,4-bis(benzyloxy)phenyl]-3,4-dihydro-2H-1-benzopyran-3-yl 3,4-bis(benzyloxy)-5-methoxybenzoate 

Relevant articles and documents

1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives

The present invention relates to 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives having pharmacological activity to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and/or prophylaxis of a cognitive disorder.

Depigmenting activity and low cytotoxicity of alkoxy benzoates or alkoxy cinnamte in cultured melanocytes

To obtain effective and safe topical depigmenting agents, we synthesized hydroxybenzoates, alkoxybenzoates, and 3,4,5-trimethoxycinnamate containing a thymol moiety and screened then for high-level inhibitory activity against melanin synthesis in cultured melanocytes. Eight compounds were tested for their depigmenting effect and cytotoxicity using a murine melanocyte cell line. We found that 3,4,5-trialkoxybenzoates and 3,4,5-trimethoxycinnamate, synthesized by conjugating 3,4,5-trialkoxybenzoic acids and 3,4,5-trimethoxycinnmic acid with thymol, showed a potent depigmenting effect and low cytotoxicity. Compound 4h, 5-methyl-2-(methylethyl)phenyl (2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoate, showed the most potent depigmenting effect (IC50=10 μM) with low cytotoxicity (IC50=200 μM).