70918-95-5

Basic information

• Product Name: 1,2-Benzenediamine,N-(1-methylethyl)-(9CI)
• Synonyms: 1,2-Benzenediamine,N-(1-methylethyl)-(9CI);N1-isopropylbenzene-1,2-diamine;N-Isopropylbenzene-1,2-diamine 2HCl
• CAS NO: 70918-95-5
• Molecular Formula: C₉H₁₄N₂
• Molecular Weight: 150.224
• Product Categories: AMINEPRIMARY
• Mol File: 70918-95-5.mol
• Article Data: 28

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1,2-Benzenediamine,N-(1-methylethyl)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Benzenediamine,N-(1-methylethyl)-(9CI)(70918-95-5)
• EPA Substance Registry System: 1,2-Benzenediamine,N-(1-methylethyl)-(9CI)(70918-95-5)

Safety Data

• Hazardous Substances Data: 70918-95-5(Hazardous Substances Data)

Usage

Description

1,2-Benzenediamine,N-(1-methylethyl)-(9CI), commonly known as N-isopropylaniline, is a chemical compound with the molecular formula C9H14N2. It is a derivative of aniline and possesses a slightly toxic and irritating effect on the skin, eyes, and respiratory system. Classified as a hazardous substance, it requires careful handling and adherence to strict safety guidelines due to its mutagenic and carcinogenic properties.

Uses

Used in Chemical Industry:
1,2-Benzenediamine,N-(1-methylethyl)-(9CI) is used as a chemical intermediate for the production of dyes, pigments, and pharmaceuticals. Its unique chemical structure allows it to serve as a building block in the synthesis of various compounds, contributing to the development of a wide range of products in the chemical industry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1,2-Benzenediamine,N-(1-methylethyl)-(9CI) is utilized as a key component in the development of certain medications. Its chemical properties make it a valuable asset in the synthesis of drugs, potentially leading to the creation of new and innovative treatments for various medical conditions.
Used in Dye and Pigment Industry:
1,2-Benzenediamine,N-(1-methylethyl)-(9CI) is employed as a crucial ingredient in the manufacturing of dyes and pigments. Its ability to form stable compounds with other chemicals enables the production of a diverse array of colorants used in various applications, such as textiles, plastics, and printing inks.

Upstream product

• 25186-42-9 N-isopropyl-2-nitroaniline 
• 95-54-5 1,2-diamino-benzene 
• 67-64-1 acetone 
• 88-74-4 2-nitro-aniline 
• 577-19-5 2-nitrophenyl bromide 
• 88-73-3 2-Chloronitrobenzene 
• 1493-27-2 ortho-nitrofluorobenzene 
• 75-31-0 isopropylamine 
• 13534-98-0 3-bromopyridin-4-amine 
• 75-26-3 isopropyl bromide 
• 768-52-5 N-Isopropylaniline 

Downstream Products

• 89659-77-8 ethyl N-(2-isopropylaminophenyl)-carbamate hydrochloride 
• 104143-42-2 3-(2-isopropylaminoanilino)-5,5-dimethyl-2-cyclohexen-1-one 
• 76060-03-2 1-isopropyl-2-(2-nitrophenyl)-2,3-dihydrobenzimidazole 
• 70918-98-8 C₃₆H₄₄N₈P₄ 
• 124-40-3 dimethyl amine 
• 35681-40-4 1,3-dihydro-1-(1-methylethyl)-2H-benzimidazol-2-one 

Relevant articles and documents

Regioselective Radical Arene Amination for the Concise Synthesis ofortho-Phenylenediamines

The formation of arene C-N bonds directly from C-H bonds is of great importance and there has been rapid recent development of methods for achieving this through radical mechanisms, often involving reactiveN-centered radicals. A major challenge associated with these advances is that of regiocontrol, with mixtures of regioisomeric products obtained in most protocols, limiting broader utility. We have designed a system that utilizes attractive noncovalent interactions between an anionic substrate and an incoming radical cation in order to guide the latter to the areneorthoposition. The anionic substrate takes the form of a sulfamate-protected aniline and telescoped cleavage of the sulfamate group after amination leads directly toortho-phenylenediamines, key building blocks for a range of medicinally relevant diazoles. Our method can deliver both free amines and monoalkyl amines allowing access to unsymmetrical, selectively monoalkylated benzimidazoles and benzotriazoles. As well as providing concise access to valuableortho-phenylenediamines, this work demonstrates the potential for utilizing noncovalent interactions to control positional selectivity in radical reactions.

TREX1 INHIBITORS AND USES THEREOF

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds for inhibiting three prime repair exonuclease 1 ("TREX1").

Rapid construction of imidazopyridines from ortho-haloaminopyridines

A practical strategy for the preparation of imidazopyridine derivatives from ortho-haloaminopyridines utilizing a two-step C-N coupling/cyclization reaction sequence has been developed. This procedure provides rapid and efficient access to many medicinally interesting imidazopyridine compounds and related imidazopyrazine/purine heterocycles.