7099-87-8

Basic information

• Product Name: 2-(4-Bromophenyl)-2-oxoacetic acid
• Synonyms: 2-(4-Bromophenyl)-2-oxoacetic acid
• CAS NO: 7099-87-8
• Molecular Formula: C₈H₅BrO₃
• Molecular Weight: 229.0275
• Mol File: 7099-87-8.mol
• Article Data: 26

Chemical Properties

• Melting Point: 89 °C
• Boiling Point: 152-155 °C(Press: 3 Torr)
• Appearance: /
• Density: 1.738±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.03±0.54(Predicted)
• CAS DataBase Reference: 2-(4-Bromophenyl)-2-oxoacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Bromophenyl)-2-oxoacetic acid(7099-87-8)
• EPA Substance Registry System: 2-(4-Bromophenyl)-2-oxoacetic acid(7099-87-8)

Safety Data

• Hazardous Substances Data: 7099-87-8(Hazardous Substances Data)

Usage

Description

2-(4-Bromophenyl)-2-oxoacetic acid is a chemical compound with the molecular formula C8H6BrO3. It is a derivative of acetic acid and contains a bromine atom attached to a phenyl group. This versatile chemical is characterized by its ability to introduce specific functional groups into organic molecules, making it a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds.

Uses

Used in Pharmaceutical Research:
2-(4-Bromophenyl)-2-oxoacetic acid is used as a building block for the synthesis of various pharmaceuticals. Its presence allows for the introduction of specific functional groups, which can enhance the activity and efficacy of the resulting drugs.
Used in Agrochemical Production:
In the agrochemical industry, 2-(4-Bromophenyl)-2-oxoacetic acid serves as an intermediate in the production of various agrochemicals. Its unique structure contributes to the development of effective and targeted pest control solutions.
Used in Organic Synthesis:
2-(4-Bromophenyl)-2-oxoacetic acid is utilized as an intermediate in the synthesis of other organic compounds. Its bromine atom facilitates the introduction of desired functional groups, making it a key component in the creation of advanced materials and fine chemicals.
Used in Manufacturing Advanced Materials:
2-(4-Bromophenyl)-2-oxoacetic acid's ability to introduce specific functional groups also makes it useful in the manufacturing of advanced materials. 2-(4-Bromophenyl)-2-oxoacetic acid plays a crucial role in developing products with improved properties and performance in various applications.

Upstream product

• 69374-79-4 2-(4-bromophenyl)-2-oxoacetamide 
• 99-73-0 para-bromophenacyl bromide 
• 108-86-1 bromobenzene 
• 4755-77-5 Ethyl oxalyl chloride 
• 6940-50-7 4-bromo-DL-mandelic acid 
• 6048-21-1 4-bromobenzoyl cyanide 
• 59036-95-2 1-[2-(4-bromo-phenyl)-2-oxo-ethyl]-pyridinium 
• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 106-37-6 1.4-dibromobenzene 
• 20201-26-7 ethyl 4-bromophenylglyoxylate 
• 58881-56-4 2,2'-thiobis[1-(4-bromophenyl)ethanone] 
• 589-87-7 1,4-bromoiodobenzene 
• 124-38-9 carbon dioxide 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 4254-18-6 1,2-bis(4-bromophenyl)-2-hydroxyethan-1-one 
• 20201-26-7 ethyl 4-bromophenylglyoxylate 
• 62551-73-9 2-oxo-2-(4-bromophenyl)acetyl chloride 
• 77483-96-6 5-(4-Bromo-phenyl)-6-hydroxy-pyrazine-2,3-dicarbonitrile 
• 1122-91-4 4-bromo-benzaldehyde 
• 72111-69-4 5-(4-bromo-phenyl)-6-chloro-pyrazine-2,3-dicarbonitrile 
• 72113-78-1 5-(4-bromo-phenyl)-6-propylamino-pyrazine-2,3-dicarbonitrile 
• 101315-56-4 3-(4-bromophenyl)quinolin-2(1H)-one 
• 101315-52-0 2-(4-Bromphenylglyoxyloylamino)benzyltriphenylphosphoniumbromid 
• 1173294-92-2 (4-bromophenyl)(2-(pyridin-2-yl)phenyl)methanone 
• 92433-07-3 N-(2-(4'-bromobenzoyl)phenyl)acetamide 
• 90-90-4 (4-bromophenyl)(phenyl)methanone 
• 1258875-43-2 3-(4-chlorophenyl)-6-(4-bromophenyl)-7H-thiazolo[3,2-b][1,2,4]triazin-7-one 
• 1258875-45-4 6-(4-bromophenyl)-3-(4-methylphenyl)-7H-thiazolo[3,2-b][1,2,4]triazin-7-one 

Relevant articles and documents

Silyl Cyanopalladate-Catalyzed Friedel-Crafts-Type Cyclization Affording 3-Aryloxindole Derivatives

3-Aryloxindole derivatives were synthesized through a Friedel-Crafts-type cyclization. The reaction was catalyzed by a trimethylsilyl tricyanopalladate complex generated in situ from trimethylsilyl cyanide and Pd(OAc) 2. Wide varieties of diethyl phosphates derived from N -arylmandelamides were converted almost quantitatively into oxindoles. When N, N -dibenzylamide was used instead of an anilide substrate, a benzo-fused δ-lactam was obtained. An oxindole product was subjected to substitution reactions to afford 3,3-diaryloxindoles with two different aryl groups.

Synthesis of Unprotected 2-Arylglycines by Transamination of Arylglyoxylic Acids with 2-(2-Chlorophenyl)glycine

The transamination of α-keto acids with 2-phenylglycine is an effective methodology for directly synthesizing unprotected α-amino acids. However, the synthesis of 2-arylglycines by transamination is problematic because the corresponding products, 2-arylglycines, transaminate the starting arylglyoxylic acids. Herein, we demonstrate the use of commercially available l-2-(2-chlorophenyl)glycine as the nitrogen source in the transamination of arylglyoxylic acids, producing the corresponding 2-arylglycines without interference from the undesired self-transamination process.

Design and synthesis of 1H-indazole-3-carboxamide derivatives as potent and selective PAK1 inhibitors with anti-tumour migration and invasion activities

Aberrant activation of p21-activated kinase 1 (PAK1) is associated with tumour progression, and PAK1 has been recognized as a promising target for anticancer drug discovery. However, the development of potent PAK1 inhibitors with satisfactory kinase selec