71079-08-8 Usage
Description
4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic Acid is a complex organic compound with a unique chemical structure. It is characterized by its benzeneacetic acid backbone, which is modified with various functional groups, including an aminoiminomethyl group and a benzoyl group. This molecule is known for its potential biological activities and applications in various fields.
Uses
Used in Pharmaceutical Industry:
4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic Acid is used as a metabolite for the development of pharmaceuticals, specifically for the prevention and control of allergies. It is derived from Camostat (C150300), a pollen protease inhibitor, which plays a crucial role in managing allergic reactions by targeting the underlying enzyme responsible for the symptoms.
Used in Research and Development:
In addition to its pharmaceutical applications, 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic Acid can be utilized in research and development for the study of enzyme inhibition, protein-protein interactions, and other biological processes. Its unique structure and functional groups make it an interesting candidate for exploring new therapeutic strategies and understanding the underlying mechanisms of various diseases.
Used in Drug Design and Optimization:
4-[[4-[(AMinoiMinoMethyl)aMino]benzoyl]oxy]benzeneacetic Acid can also be employed in drug design and optimization processes, where its chemical properties and interactions with target proteins can be investigated. By studying the structure-activity relationship of 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic Acid and its analogs, researchers can potentially develop more effective and selective inhibitors for various therapeutic targets.
Check Digit Verification of cas no
The CAS Registry Mumber 71079-08-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,1,0,7 and 9 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 71079-08:
(7*7)+(6*1)+(5*0)+(4*7)+(3*9)+(2*0)+(1*8)=118
118 % 10 = 8
So 71079-08-8 is a valid CAS Registry Number.
71079-08-8Relevant articles and documents
Hydrolytic profile for ester- or amide-linkage by carboxylesterases pI 5.3 and 4.5 from human liver
Takai, Satomi,Matsuda, Ayuka,Usami, Yoshiko,Adachi, Tetsuo,Sugiyama, Tadashi,Katagiri, Yoshihiro,Tatematsu, Masae,Hirano, Kazuyuki
, p. 869 - 873 (2007/10/03)
Carboxylesterases (EC 3.1.1.1) from human liver were purified using Q- Sepharose, Sephadex G-150, isoelectrofocusing and Con A-Sepharose. The calculated molecular mass of the pI 5.3 enzyme was 120 kDa and 61 kDa from the results of Sephadex G-150 gel filtration and SDS-polyacrylamide gel electrophoresis (PAGE), respectively, suggesting that this enzyme is a dimer. On the other hand, carboxylesterase pI 4.5, with a molecular-mass of 64 kDa, was a monomer. The activities of both enzymes were inhibited by typical serine enzyme inhibitors. Amino acid sequence analysis of the purified enzymes pI 5.3 and 4.5 showed high homology with rabbit carboxylesterase form 1 and 2, respectively. The results also suggested that carboxylesterase pI 5.3 is identical to the deduced amino acid sequence from cDNA for HUI, and that carboxylesterase pI 4.5 is identical to the deduced amino acid sequence from the cDNA registered as human carboxylesterase (hCE-2) in GenBank. We first purified carboxylesterase pI 4.5 and investigated its hydrolytic activity upon various drugs. The two enzymes differed in substrate specificity. Prodrugs of angiotensin-converting enzyme inhibitors, such as delapril and imidapril, were converted to active metabolites by carboxylesterase pI 5.3, but not by carboxylesterase pI 4.5. The hydrolysis velocity of temocapril by carboxylesterase pI 5.3 was 12-fold faster than by carboxylesterase pI 4.5. In contrast, aspirin oxybutynin and procaine were hydrolyzed by only carboxylesterase pI 4.5. We also found that an amide- linkage in drugs, except for that in aniracetam was not a good substrate for the two enzymes. Consequently, carboxylesterases pI 5.3 and 4.5 maybe involved in the metabolism of various drugs containing an ester-linkage.
Guanidinobenzoic acid compounds and process for preparing the same
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, (2008/06/13)
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