71146-77-5Relevant articles and documents
Synthesis and initial preclinical evaluation of the P2X7 receptor antagonist [11C]A-740003 as a novel tracer of neuroinflammation
Janssen, Bieneke,Vugts, Danielle J.,Funke, Uta,Spaans, Arnold,Schuit, Robert C.,Kooijman, Esther,Rongen, Marissa,Perk, Lars R.,Lammertsma, Adriaan A.,Windhorst, Albert D.
, p. 509 - 516 (2014)
Neuroinflammation, in particular activation of microglia, is thought to play an important role in the progression of neurodegenerative diseases. In activated microglia, the purinergic P2X7 receptor is upregulated. A-740003, a highly affine and