7119-09-7

Basic information

• Product Name: 1-bromo-4-(3,3,3-trifluoro-1-propyn-1-yl)benzene
• Synonyms: 1-bromo-4-(3,3,3-trifluoro-1-propyn-1-yl)benzene
• CAS NO: 7119-09-7
• Molecular Weight: 249.03
• Mol File: 7119-09-7.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1-bromo-4-(3,3,3-trifluoro-1-propyn-1-yl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-4-(3,3,3-trifluoro-1-propyn-1-yl)benzene(7119-09-7)
• EPA Substance Registry System: 1-bromo-4-(3,3,3-trifluoro-1-propyn-1-yl)benzene(7119-09-7)

Safety Data

• Hazardous Substances Data: 7119-09-7(Hazardous Substances Data)

Upstream product

• 766-96-1 4-bromo-1-ethynylbenzene 
• 1122-91-4 4-bromo-benzaldehyde 
• 67205-73-6 2-(4-bromophenyl)-1-(4-methoxyphenyl)-1-ethanone 
• 77152-08-0 trifluoromethylcopper(I) 
• 118520-70-0 1-copper(I) (4-bromophenyl)ethyne 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 147531-11-1 trifluoromethanesulfonic acid diphenyl(trifluoromethyl)sulfonium salt 
• 887144-97-0 Togni's reagent 

Downstream Products

• 13541-18-9 1-(4-bromophenyl)-3,3,3-trifluoropropan-1-one 
• 1111072-22-0 (E)-1-bromo-4-(3,3,3-trifluoro-1-iodoprop-1-enyl)benzene 
• 7119-18-8 4-Dimethylamino-4'-<3,3,3-trifluor-propionyl>-azobenzol 
• 7119-16-6 1-<4-Amino-phenyl>-3,3,3-trifluor-propan-1-on 
• 7211-83-8 4-(3,3,3-Trifluor-prop-1-inyl)-benzoesaeureazid 
• 950-04-9 4-(3,3,3-trifluoroprop-1-ynyl)benzoic acid 

Relevant articles and documents

Regioselective Gold-Catalyzed Hydration of CF3- and SF5-alkynes

The regioselective gold-catalyzed hydration of CF3- and SF5-alkynes is described. The corresponding trifluoromethylated and pentasulfanylated ketones are obtained in up to 91% yield as single regioisomers showcasing the use of CF3 and SF5 as highly efficient directing groups in this reaction. Notably, this transformation represents the first use of CF3- and SF5-alkynes in gold catalysis.

Domino Hydroboration/Trifluoromethylation of Alkynes Using Fluoroform-Derived [CuCF3]

A domino hydroboration/trifluoromethylation (formal hydrotrifluoromethylation) of alkynes using the fluoroform-derived [CuCF3] reagent is achieved. Synthetically useful (E)-alkenyl-CF3 building blocks and 1,1-bis(trifluoromethyl)-substituted alkenes can be prepared under ambient conditions in one pot/one step from alkynes. The ultimate source of CF3 is the inexpensive industrial waste fluoroform.

Fluoroform-Derived CuCF3 for Trifluoromethylation of Terminal and TMS-Protected Alkynes

An efficient trifluoromethylation reaction of alkynes using a fluoroform-derived CuCF3 reagent is described. The CF3 source is the inexpensive industrial waste fluoroform (CF3H). The air-stable CuCF3 reagent can be prepared in large quantities and is convenient to use. Synthetically useful trifluoromethylated alkynes containing a wide range of functional groups were successfully synthesized under mild conditions. Both terminal and TMS-protected alkynes gave the products in one step. The beneficial effect of a diamine ligand tetramethylethylenediamine (TMEDA) with the fluoroform-derived CuCF3 reagent was also demonstrated.