71225-69-9

Basic information

• Product Name: Methanone, (2-chlorophenyl)phenyl-, oxime
• CAS NO: 71225-69-9
• Molecular Formula: C13H10ClNO
• Molecular Weight: 231.681
• Mol File: 71225-69-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Methanone, (2-chlorophenyl)phenyl-, oxime(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, (2-chlorophenyl)phenyl-, oxime(71225-69-9)
• EPA Substance Registry System: Methanone, (2-chlorophenyl)phenyl-, oxime(71225-69-9)

Safety Data

• Hazardous Substances Data: 71225-69-9(Hazardous Substances Data)

Upstream product

• 5162-03-8 (2-chlorophenyl)(phenyl)methanone 
• 71-43-2 benzene 
• 49660-38-0 2-chlorobenzonitrile oxide 
• 609-65-4 o-chlorobenzoyl chloride 
• 119-61-9 benzophenone 
• 108-90-7 chlorobenzene 
• 98-88-4 benzoyl chloride 

Downstream Products

• 6833-13-2 2-chlorobenzanilide 
• 55095-13-1 α-(2-chlorophenyl)phenylmethylamine 
• 1020-39-9 N-(2-chlorophenyI)benzamide 
• 5267-36-7 (RS)-(2-chlorophenyl)phenylmethylamine hydrochloride 
• 5162-03-8 (2-chlorophenyl)(phenyl)methanone 

Relevant articles and documents

MODULATORS OF TREX1

Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compositons thereof, which are useful for treating a variety of conditions associated with TREX1.

Palladium-catalyzed ortho-selective C-H bond chlorination of aromatic ketones

A palladium-catalyzed ortho-selective C-H bond chlorination reaction for the preparation of 2-chloro aromatic ketones was described. Both electron-withdrawing and electron-donating groups on the aromatic rings are well tolerated under the optimized conditions. The 2-chloro aromatic ketones obtained by our method could be applied to synthesize the derivatives of 1H-indazole or benzo[d]isoxazole.

Synthesis of 3-substituted indazoles and benzoisoxazoles via Pd-catalyzed cyclization reactions: application to the synthesis of nigellicine

Syntheses of 3-substituted indazoles and benzoisoxazoles were efficiently accomplished with the aid of Pd-catalyzed intramolecular carbon-nitrogen and carbon-oxygen bond formations. The catalyst system described herein allows the cyclization to proceed under very mild conditions and thus could be applied to a wide range of substrates with acid- or base-sensitive functional groups. A total synthesis for the indazole ring-containing natural product nigellicine is also described.