71229-85-1

Basic information

• Product Name: 4-Bromo-1-ethyl-1H-pyrazole
• Synonyms: Albb-004431;4-bromo-1-ethyl-1H-pyrazole(SALTDATA: FREE);4-Bromo-1-ethylpyrazole ;-Bromo-1-ethylpyrazole
• CAS NO: 71229-85-1
• Molecular Formula: C₅H₇BrN₂
• Molecular Weight: 175.03
• Product Categories: blocks;Bromides;Halides;Pyrazoles & Triazoles;Pyrazoles & Triazoles
• Mol File: 71229-85-1.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 108°C/20mmHg(lit.)
• Flash Point: 81.687 °C
• Appearance: /
• Density: 1.572 g/cm³
• Vapor Pressure: 0.265mmHg at 25°C
• Refractive Index: 1.5170 to 1.5210
• Storage Temp.: 2-8°C
• PKA: 0.23±0.10(Predicted)
• CAS DataBase Reference: 4-Bromo-1-ethyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-1-ethyl-1H-pyrazole(71229-85-1)
• EPA Substance Registry System: 4-Bromo-1-ethyl-1H-pyrazole(71229-85-1)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 71229-85-1(Hazardous Substances Data)

Usage

General Description

4-Bromo-1-ethyl-1H-pyrazole is a chemical compound with the molecular formula C6H8BrN2. It is a pyrazole derivative with a bromine atom and an ethyl group attached to the nitrogen atoms of the pyrazole ring. 4-Bromo-1-ethyl-1H-pyrazole is primarily used in chemical research and synthesis, and it has potential applications in pharmaceuticals and agrochemicals. It is known for its reactivity and versatility in forming various derivatives and molecular structures. Its unique properties make it a valuable building block in the development of new chemical compounds for a wide range of industrial and scientific purposes.

InChI:InChI=1/C5H7BrN2/c1-2-8-4-5(6)3-7-8/h3-4H,2H2,1H3

Upstream product

• 2075-45-8 4-bromo-1H-pyrazole 
• 74-96-4 ethyl bromide 
• 75-03-6 ethyl iodide 
• 2817-71-2 1-ethyl-1H-pyrazole 

Downstream Products

• 847818-56-8 (1-ethyl-1H-pyrazol-4-yl)boronic acid 
• 847818-70-6 1-ethyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole 
• 304903-10-4 1-ethyl-1H-pyrazole-4-carbaldehyde 
• 1430725-01-1 N-(3-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)acetamide 
• 1430728-84-9 3-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)aniline 
• 1430725-02-2 N-(3-(5-(1-ethyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(1H-pyrrol-1-yl)phenyl)ethanesulfonamide 
• 1782070-22-7 3-((6-chloro-2-cyclopropyl-1-(1-ethyl-1H-pyrazol-4-yl)-7-fluoro-1H-indol-3-yl)thio)-2-fluorobenzoic acid 

Relevant articles and documents

Pyrazole N-alkylation method

The invention provides a pyrazole N-alkylation method. Pyrazole or pyrazole derivatives and alkyl halogenated hydrocarbons react in a solvent under the existence of quaternary ammonium salt catalysts;N-alkyl substituted pyrazole is obtained. The method provided by the invention has the advantages that the operation is simple; the cost is low; the anhydrous oxygen-free environment is not needed; heating is not needed; the yield is high; the amplified industrialized production can be easily realized.

PROTEIN KINASE INHIBITORS

A compound of formula (I), wherein R3, R4, G, B, M, and Z are as defined in the claims, and pharmaceutically acceptable salts thereof are disclosed. The compounds of formula (I) possess utility as FGFR inhibitors and are useful in the treatment of a condition, where FGFR kinase inhibition is desired, such as cancer.

AUTOTAXIN INHIBITOR COMPOUNDS

Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorde