71236-74-3Relevant articles and documents
Changing selectivity of DNA oxidation from deoxyribose to guanine by ligand design and a new binuclear copper complex
Li, Lei,Karlin, Kenneth D.,Rokita, Steven E.
, p. 520 - 521 (2005)
A dinuclear copper complex [CuII2(PD-O)(H2O)2]3+ (1) (where PD-OH is a pyridylalkylamine containing binucleating ligand) promotes guanine oxidation in single-stranded DNA in the presence of 3-mercaptopropionic acid and dioxygen. This reaction is detected after subsequent piperidine treatment. Little spontaneous strand scission indicative of deoxyribose oxidation is observed in contrast to the results known for other copper complexes. Chemical characterization and nanospray ionization mass spectrometry analysis of oligodeoxynucleotides treated with 1 suggest conversion of guanine residues to their 2,6-diamino-5-formamidino-4-hydroxypyrimidine (+18 amu) and possibly 5,8-dihydroxy-7,8-dihydroguanine (+34 amu) derivatives. The selectivity toward nucleobase rather than deoxyribose oxidation is discussed in terms of the specific nature of the dicopper (hydro)peroxo species formed with the PD-OH ligand versus the intermediates formed in the presence of other binucleating ligands. Copyright
Self-assembly, crystal structure, and magnetic properties of a phenoxo- bridged tetranuclear Cu(II) complex of the [2 x 2] grid type
Rojo, Javier,Lehn, Jean-Marie,Baum, Gerhard,Fenske, Dieter,Waldmann, Oliver,Mueller, Paul
, p. 517 - 522 (2007/10/03)
The ditopic ligand 3 has been synthesized. In its deprotonated form, it reacts with copper(II) ions to form a tetranuclear complex 1 of the [2 x 2] Cu4(II) grid type, the structure of which has been confirmed by X-ray crystallography. Magnetic studies of complex 1 indicate a very weak antiferromagnetic coupling between the phenoxo-bridged Cu(II) ions.
