71291-54-8

Basic information

• Product Name: 2-(3-anisyl)-Δ¹-pyrroline
• Synonyms: 2-(3-anisyl)-Δ¹-pyrroline
• CAS NO: 71291-54-8
• Molecular Weight: 175.23
• Mol File: 71291-54-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-(3-anisyl)-Δ¹-pyrroline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-anisyl)-Δ¹-pyrroline(71291-54-8)
• EPA Substance Registry System: 2-(3-anisyl)-Δ¹-pyrroline(71291-54-8)

Safety Data

• Hazardous Substances Data: 71291-54-8(Hazardous Substances Data)

Upstream product

• 628-20-6 4-Chlorobutyronitrile 
• 36282-40-3 (3-methoxyphenyl)magnesium bromide 
• 38102-72-6 4-oxo-4-(3-methoxyphenyl)butanenitrile 
• 2398-37-0 3-methoxyphenyl bromide 
• 161564-41-6 2-oxopyrrolidine-1-carbaldehyde diethyl acetal 
• 914954-34-0 tert-butyl (4-(3-methoxyphenyl)-4-oxobutyl)carbamate 
• 14468-90-7 N-trimethylsilyl-pyrrolidin-2-one 
• 616-45-5 2-pyrrolidinon 
• 10259-22-0 ethyl 3-methoxybenzoate 
• 586-38-9 3-Methoxybenzoic acid 
• 1202643-83-1 1-(3-methoxyphenyl)cyclobutan-1-ol 

Downstream Products

• 102236-69-1 3-(4,5-dihydro-3H-pyrrol-2-yl)-phenol 
• 103861-77-4 2-(3-methoxyphenyl)pyrrolidine 
• 1228556-79-3 (+)-2-(3-OMe-phenyl)-1-pyrrolidine 
• 1228556-79-3 (-)-2-(3-OMe-phenyl)-1-pyrrolidine 
• 1315512-53-8 C₁₆H₂₃NO₃ 
• 1228556-79-3 (+)-2-(3-methoxyphenyl)pyrrolidine 
• 71291-41-3 4-(3-methoxy-phenyl)-3-(2-pyrrolidin-1-yl-propyl)-1,5,6,7-tetrahydro-azepin-2-one 
• 71291-53-7 4-(3-hydroxy-phenyl)-3-(2-piperidin-1-yl-propyl)-1,5,6,7-tetrahydro-azepin-2-one 
• 71291-40-2 4-(3-methoxy-phenyl)-3-(2-piperidin-1-yl-propyl)-1,5,6,7-tetrahydro-azepin-2-one 

Relevant articles and documents

Palladium-catalyzed ortho-olefination of 2-arylpyrrolidines: A tool for increasing structural complexity in nitrogen heterocycles

The dual role of the (2-pyridyl)sulfonyl unit as directing functionality and readily removable N-protecting group has enabled an efficient and practical transformation of 2-arylpyrrolidine derivatives into more complex tricyclic frameworks via palladium-catalyzed ortho-olefination with electron deficient alkenes and subsequent cyclization upon N-deprotection under mild conditions. The key cross coupling step in the presence of N-fluoro-2,4,6-trimethylpyridinium triflate ([F+]) as the terminal oxidant is both highly efficient and tolerant to a variety of steric and electronic changes at both coupling partners. By adequate choice of reductive conditions, the N-sulfonyl deprotection can be directed to the selective formation of benzo-fused pyrrolizidine or fused pyrrolidino-benzazapine frameworks.

Design, synthesis and biological evaluation of N-hydroxy-aminobenzyloxyarylamide analogues as novel selective κ opioid receptor antagonists

Aminobenzyloxyarylamide derivatives 1a-i and 2a-t were designed and synthesized as novel selective κ opioid receptor (KOR) antagonists. The benzoyl amide moiety of LY2456302 was changed into N-hydroxybenzamide and benzisoxazole-3(2H)-one to investigate whether it could increase the binding affinity or selectivity for KOR. All target compounds were evaluated in radioligand binding assays for opioid receptor binding affinity. These efforts led to the identification of compound 1c (κ Ki = 179.9 nM), which exhibited high affinity for KOR. Moreover, the selectivity of KOR over MOR and DOR increased nearly 2-fold and 7-fold, respectively, compared with (±)LY2456302.

Iridium-catalyzed enantioselective hydrogenation of cyclic imines

A catalytic complex made from [Ir(COD)Cl]2 [di-μ-chloro- bis(1,5-cyclooctadiene)diiridium(I)] precursor and (S,S)-f-Binaphane ((R,R)-1,1′-bis{(R)-4,5-dihydro-3H-dinaphtho[1,2-c:2′,1′-e] phosphepino}ferrocene) ligand effectively catalyzed the en