713-45-1

Basic information

• Product Name: 1-(4-(trifluoroMethyl)phenyl)propan-2-one
• Synonyms: 1-(4-(trifluoroMethyl)phenyl)propan-2-one;4-(trifluoromethyl)phenylacetone
• CAS NO: 713-45-1
• Molecular Formula: C₁₀H₉F₃O
• Molecular Weight: 202.1730696
• Mol File: 713-45-1.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 214.982°C at 760 mmHg
• Flash Point: 95.755°C
• Appearance: /
• Density: 1.194g/cm³
• Vapor Pressure: 0.151mmHg at 25°C
• Refractive Index: 1.449
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(4-(trifluoroMethyl)phenyl)propan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-(trifluoroMethyl)phenyl)propan-2-one(713-45-1)
• EPA Substance Registry System: 1-(4-(trifluoroMethyl)phenyl)propan-2-one(713-45-1)

Safety Data

• Hazardous Substances Data: 713-45-1(Hazardous Substances Data)

Usage

Description

1-(4-(trifluoroMethyl)phenyl)propan-2-one is an organic compound with the chemical formula C10H9F3O. It is characterized by the presence of a trifluoromethyl group attached to a phenyl ring, which is connected to a propan-2-one moiety. 1-(4-(trifluoroMethyl)phenyl)propan-2-one exhibits unique chemical properties due to the presence of the trifluoromethyl group, making it a versatile building block in organic synthesis.

Uses

Used in Pharmaceutical Industry:
1-(4-(trifluoroMethyl)phenyl)propan-2-one is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with improved potency, selectivity, and reduced side effects.
Used in Chemical Research:
1-(4-(trifluoroMethyl)phenyl)propan-2-one serves as a valuable research tool in the field of organic chemistry. It is used to study the reactivity and selectivity of various chemical reactions, as well as to develop new synthetic methodologies.
Used in Material Science:
1-(4-(trifluoroMethyl)phenyl)propan-2-one is employed in the development of novel materials with specific properties, such as improved thermal stability, chemical resistance, or enhanced electrical conductivity.
Used in the Preparation of P,N-type Phosphine Ligands:
1-(4-(trifluoroMethyl)phenyl)propan-2-one is used in the preparation of a highly congested carbazoyl-derived P,N-type phosphine ligand. This ligand exhibits excellent catalytic activity in the Pd-catalyzed acetone monoarylations, a reaction of significant importance in the synthesis of various organic compounds.

InChI:InChI=1/C10H9F3O/c1-7(14)6-8-2-4-9(5-3-8)10(11,12)13/h2-5H,6H2,1H3

Upstream product

• 402-43-7 p-trifluoromethylphenyl bromide 
• 75-56-9 methyloxirane 
• 402-51-7 4-(trifluoromethyl)phenylmagnesium bromide 
• 78-95-5 chloroacetone 
• 42006-43-9 (E)-1-(prop-1-en-1-yl)-4-(trifluoromethyl)benzene 
• 79756-87-9 1-(prop-1-ynyl)-4-trifluoromethylbenzene 
• 108-22-5 Isopropenyl acetate 
• 1833-53-0 2-(Trimethylsilyloxy)propene 
• 123-54-6 acetylacetone 
• 455-13-0 4-Iodobenzotrifluoride 
• 67-64-1 acetone 
• 98-56-6 4-chlorobenzotrifluoride 
• 455-14-1 4-trifluoromethylphenylamine 
• 1813-97-4 1-allyl-4-(trifluoromethyl)benzene 

Downstream Products

• 14276-90-5 2-Methyl-1-(p-trifluormethylphenyl)-2-butanol 
• 185557-06-6 5-Hydroxy-5-methyl-4-(4-trifluoromethyl-phenyl)-5H-furan-2-one 
• 274915-12-7 3-[2-oxo-1-(4-trifluoromethylphenyl)propyl]-4-ethoxycyclobut-3-ene-1,2-dione 
• 864370-26-3 6-methyl-4-methylsulfanyl-2-oxo-5-(4-trifluoromethyl-phenyl)-2H-pyran-3-carbonitrile 
• 185557-18-0 6-Chloro-3-methyl-4-(4-trifluoromethyl-phenyl)-pyridazine 
• 185557-12-4 6-Methyl-5-(4-trifluoromethyl-phenyl)-2H-pyridazin-3-one 
• 79287-56-2 5-(7-Chloro-quinolin-4-ylamino)-3-diethylaminomethyl-4'-trifluoromethyl-biphenyl-2-ol 
• 79287-58-4 5-(7-Chloro-1-oxy-quinolin-4-ylamino)-3-diethylaminomethyl-4'-trifluoromethyl-biphenyl-2-ol 
• 79287-57-3 3-(tert-Butylamino-methyl)-5-(7-chloro-quinolin-4-ylamino)-4'-trifluoromethyl-biphenyl-2-ol; hydrochloride 
• 14276-93-8 2-Methyl-1-(p-trifluormethylphenyl)-butan 
• 864878-71-7 2-methyl-1-(4-(trifluoromethyl)phenyl)propan-2-ol 
• 1309380-75-3 1-(p-trifluoromethylphenyl)-2-propanone oxime 
• 1262155-48-5 C₂₀H₁₆F₃NO₃S 
• 1333377-94-8 1,2-di-p-tolyl-3-(4-(trifluoromethyl)phenyl)pentane-1,4-dione 

Relevant articles and documents

A facile, microwave-assisted, palladium-catalyzed arylation of acetone

We report an expedient method for the heteroarylation of acetone under tin-free conditions. The coupling is performed using the commercially available enol silane of acetone (2-trimethylsilyloxypropene) and a corresponding aryl bromide, chloride or triflate under microwave-assisted conditions, with tris(dibenzylideneacetone)dipalladium (Pd2(dba)3) or palladium acetate (Pd(OAc)2) and 2-(2′,6′-dimethoxybiphenyl)dicyclohexylphosphine (S-Phos) as the catalyst system.

Aryl C-F bond functionalization preparation method

The invention relates to the technical field of organic compound synthesis, in particular to an aryl C-F bond functionalization preparation method. A fluorobenzene compound and a nucleophilic reagent react under the action of a composite catalyst, wherein the composite catalyst is formed by mixing a visible light catalyst and a metal catalyst. The photocatalyst is adopted, the reaction process is safe and controllable, and operation in the preparation and production process is simplified; a purple LED is used as a reaction energy source and is green and environment-friendly, the energy utilization rate is high, and conversion from light energy to chemical energy can be efficiently realized; in the reaction, a simple nucleophilic reagent is used for attacking free radical cation species generated under a visible light catalysis condition, so that a target product with an extremely wide range is efficiently and greenly prepared; the operation steps are simplified, and the reaction route is shortened; and moreover, the forward reaction rate is high, and the production efficiency is remarkably improved.

Direct Synthesis of Propen-2-yl Sulfones through Cascade Reactions Using Calcium Carbide as an Alkyne Source

A simple method for the construction of propen-2-yl sulfones through cascade reactions of calcium carbide with arylsulfonylhydrazones using copper as a mediator is described. The salient features of this protocol are the use of readily available and easy-to-handle alkyne source, broad substrate scope, open-air condition, and simple operation procedure.