7137-29-3Relevant articles and documents
Synthesis of a NO-releasing prodrug of rofecoxib
Engelhardt, F. Conrad,Shi, Yao-Jun,Cowden, Cameron J.,Conlon, David A.,Pipik, Brenda,Zhou, George,McNamara, James M.,Dolling, Ulf-H.
, p. 480 - 491 (2006)
A newly developed synthesis of a NO-releasing prodrug of rofecoxib is described. The highly productive process consists of five chemical steps and produces prodrug 1 in an overall 64% yield from commercially available 3-phenyl-2-propyn-1-ol (4). The synth