714249-80-6

Basic information

• Product Name: 2'-C-methyl-6-O-methyl-guanosine
• Synonyms: 2'-C-methyl-6-O-methyl-guanosine;(2R,3R,4R,5R)-2-(2-AMino-6-Methoxy-9H-purin-9-yl)-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-3,4-diol;2-(2-Amino-6-methoxy-purin-9-yl)-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol;EOS-60514
• CAS NO: 714249-80-6
• Molecular Formula: C₁₂H₁₇N₅O₅
• Molecular Weight: 311.2974
• Mol File: 714249-80-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 690.2±65.0 °C(Predicted)
• Appearance: /
• Density: 1.82
• PKA: 13.13±0.70(Predicted)
• CAS DataBase Reference: 2'-C-methyl-6-O-methyl-guanosine(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-C-methyl-6-O-methyl-guanosine(714249-80-6)
• EPA Substance Registry System: 2'-C-methyl-6-O-methyl-guanosine(714249-80-6)

Safety Data

• Hazardous Substances Data: 714249-80-6(Hazardous Substances Data)

Usage

General Description

2'-C-methyl-6-O-methyl-guanosine is a chemical compound that belongs to the class of guanosine derivatives. It is composed of a guanine base attached to a ribose sugar, with a methyl group at the 2' carbon of the ribose and another methyl group at the 6' carbon of the guanine. This modification results in increased stability and resistance to degradation of the compound, making it useful in various pharmaceutical and biochemical research applications. 2'-C-methyl-6-O-methyl-guanosine has been studied for its potential anti-viral activity and as a building block for nucleic acid analogs with improved properties. It is also utilized as a molecular probe for studying RNA structure and function.

Upstream product

• 124-41-4 sodium methylate 
• 641571-44-0 (2R,3R,4R,5R)-2-(2-amino-6-chloro-9H-purin-9-yl)-5-(benzoyloxymethyl)-3-methyltetrahydrofuran-3,4-diyl dibenzoate 
• 10310-21-1 2-Amino-6-chloropurin 
• 15397-15-6 1,2,3,5-tetra-O-benzoyl-2-C-methyl-β-D-ribofuranose 
• 10310-21-1 2-amino-6-chloropurine 
• 67-56-1 methanol 

Downstream Products

• 1234491-54-3 (2R,3R,4R,5R)-2-(2-(4-fluorobenzylamino)-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol 
• 1234490-75-5 benzyl (2S)-(((2R,3R,4R,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy(naphthalene-1-yloxy)phosphorylamino)propanoate 
• 1234490-83-5 INX-08189 
• 1234490-89-1 (2S)-cyclohexyl 2-((((2R,3R,4R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(naphthalene-1-yloxy)phosphorylamino)propanoate 
• 1350765-20-6 (25,2'5)-dicyclohexyl-((((2R,35,4R,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy) phosphoryl)-(2,2')-bis-amino-dipropanoate 
• 1350765-21-7 2-amino-6-methoxy-9-(2'-C-methyl-β-D-ribofuranosyl)purine-5'-O-bis(benzoxy-L-alaninyl)phosphate 
• 1350765-22-8 C₃₄H₄₄N₇O₁₀P 
• 1350765-73-9 (2S,2'S)-dicyclohexyl 2,2'-((((2R,3R,4R,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)phosphoryl)bis(azanediyl)bis(2-phenylacetate) 
• 1350765-89-7 (2S)-neopentyl 2-((((2R,3R,4R,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(benzylamino)phosphorylamino)propanoate 
• 1350765-85-3 (2S)-benzyl 2-((((2R,3R,4R,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(butylamino)phosphorylamino)propanoate 
• 1384068-28-3 benzyl 2(S)-(((2R,3R,4R,5R)-5-(2-amino-8-iodo-6-methoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy(naphthalene-1-yloxy)phosphorylamino)propanoate 
• 1384068-42-1 (2S,2'S)-benzyl 2,2'-((((2R,3R,4R,5R)-5-(2-amino-8-iodo-6-methoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)phosphoryl)bis(azanediyl)dipropanoate 
• 1401699-50-0 6-methoxy-N-[(4-methoxyphenyl)(diphenyl)-methyl]-9-(2-C-methyl-b-d-ribofuranosyl)-9H-purin-2-amine 
• 1401699-51-1 N2-(4-methoxytrityl)-2’,O6-dimethyl-2’,3’,5’-tris-O-(trimethylsilyl)guanosine 

Relevant articles and documents

Synthesis of 2′-Methyl-6-methoxyguanosine from the Parent Ribonucleoside Guanosine

A short and efficient synthesis of the nucleoside fragment contained in the NS5B nucleoside inhibitor BMS-986094 was achieved in 23% overall yield on a gram scale. The synthesis uses the widely available starting material guanosine via a short sequence ending in a Mukaiyama hydration reaction to establish the key tertiary alcohol moiety and set the C-2′ methyl stereogenic center. This work resulted in a robust and scalable approach to this complex nucleoside.

O-(substituted benzyl) phosphoramidate compounds and therapeutic use

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COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS

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