7147-91-3

Basic information

• Product Name: N,N-bis(2-hydroxyethyl)-2-phenylacetamide
• CAS NO: 7147-91-3
• Molecular Formula: C₁₂H₁₇NO₃
• Molecular Weight: 223.2683
• Mol File: 7147-91-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 436.8°C at 760 mmHg
• Flash Point: 218°C
• Density: 1.189g/cm³
• Vapor Pressure: 2.1E-08mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: N,N-bis(2-hydroxyethyl)-2-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-bis(2-hydroxyethyl)-2-phenylacetamide(7147-91-3)
• EPA Substance Registry System: N,N-bis(2-hydroxyethyl)-2-phenylacetamide(7147-91-3)

Safety Data

• Hazardous Substances Data: 7147-91-3(Hazardous Substances Data)

Upstream product

• 101-97-3 Ethyl 2-phenylethanoate 
• 111-42-2 2,2'-iminobis[ethanol] 
• 101-41-7 benzeneacetic acid methyl ester 
• 103-82-2 phenylacetic acid 

Relevant articles and documents

Carboxyl activation of 2-mercapto-4,6-dimethylpyrimidine through n-acyl-4,6-dimethylpyrimidine-2-thione: A chemical and spectrophotometric investigation

2-Mercapto-4,6-dimethylpyrimidine, as effective carboxyl activating group, has been successfully proved by converting it into respective acyl derivatives and the subsequent conversion to the amides and esters respectively using amines, amino alcohols and alcohols. The aminolysis and esterification were monitored chemically and spectrophotometrically. This paved way to establish that the above mercaptopyrimidine derivative is an efficient carboxyl activating group applicable in solid phase peptide synthesis.

Carboxyl activation of 3-mercapto-5,6-diphenyl-1,2,4-triazine through N-phenylacetyl-5,6-diphenyl-1,2,4-triazine-3-thione

The carboxyl activation ability of 3-mercapto-5,6-diphenyl-1,2,4-triazine has been established by coverting it into N-phenylacetyl-5,6-diphenyl-1,2,4-triazine-3-thione and this was then subjected to aminolysis and esterification with amines and alcohols respectively and selective aminolysis with aminoalcohols-monitoring chemically and confirmed spectrophotometrically by UV-Visible scannings. It could be proved that 3- mercapto-5,6-diphenyl-1,2,4-triazine is an efficient carboxyl activating group which can be successfully applied in solid phase peptide synthesis.