715-80-0

Basic information

• Product Name: Ethanone, 2,2-difluoro-1-(1-naphthalenyl)- (9CI)
• Synonyms: Ethanone, 2,2-difluoro-1-(1-naphthalenyl)- (9CI);2,2-Difluoro-1-naphthalen-1-yl-ethanone
• CAS NO: 715-80-0
• Molecular Formula: C12H8F2O
• Molecular Weight: 206.1881264
• Product Categories: ACETYLHALIDE
• Mol File: 715-80-0.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 2,2-difluoro-1-(1-naphthalenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2,2-difluoro-1-(1-naphthalenyl)- (9CI)(715-80-0)
• EPA Substance Registry System: Ethanone, 2,2-difluoro-1-(1-naphthalenyl)- (9CI)(715-80-0)

Safety Data

• Hazardous Substances Data: 715-80-0(Hazardous Substances Data)

Upstream product

• 686-11-3 N,N-diethyl-2,2-difluoroacetamide 
• 90-11-9 1-Bromonaphthalene 
• 413598-04-6 (2,2-difluoro-1-naphthalen-1-yl-vinyloxy)-trimethyl-silane 
• 6500-37-4 2,2,2-trifluoro-1-(naphthalen-1-yl)ethanone 
• 1200401-13-3 C₁₃H₁₁F₂N 
• 1195886-74-8 1-(2,2-difluoro-1-((2-methoxyethoxy)methoxy)vinyl)naphthalene 
• 76103-97-4 3-(naphthalene-1-yl)-3-oxopropanoic acid 
• 115262-01-6 [bromo(difluoro)methyl]-trimethyl-silane 
• 879-18-5 naphthalene-1-carbonic acid chloride 
• 86-55-5 1-naphthalenecarboxylic acid 
• 65864-64-4 trimethyl(difluoromethyl)silane 
• 14040-11-0 tungsten hexacarbonyl 
• 65094-22-6 diethyl (bromodifluoromethyl)phosphonate 
• 13922-41-3 1-Naphthylboronic acid 

Downstream Products

• 112260-69-2 2-fluoro-1-(naphthalen-1-yl)ethanone 

Relevant articles and documents

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Direct and Chemoselective Synthesis of Tertiary Difluoroketones via Weinreb Amide Homologation with a CHF2-Carbene Equivalent

The homologation of Weinreb amides into difluoromethylketones with a formal nucleophilic CHF2 transfer agent is reported. Activating TMSCHF2 with potassium tert-amylate enables a convenient access to the difluorinated homologation re

Difluoromethylation of carboxylic acids via the addition of difluorinated phosphorus ylide to acyl chlorides

A one-step protocol for the difluoromethylation of carboxylic acids is described. The reaction involves the interaction of intermediate acyl chlorides with in situ generated difluorinated phosphorus ylide Ph3P=CF2. Aromatic acids can be selectively transformed within one step either to bis-difluoromethylated alcohols or to difluorinated ketones depending on the particular reaction conditions. For bulky α-branched carboxylic acids, only ketones are produced.