716362-10-6

Basic information

• Product Name: 6-Chloro-4-methoxynicotinic acid
• Synonyms: 3-Pyridinecarboxylic acid, 6-chloro-4-Methoxy-;6-Chloro-4-methoxy-3-pyridinecarboxylic acid;6-Chloro-4-methoxynicotinic acid;6-chloro-4-Methoxypyridine-3-carboxylic acid
• CAS NO: 716362-10-6
• Molecular Formula: C₇H₆ClNO₃
• Molecular Weight: 187.58
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 716362-10-6.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Density: 1.430
• Refractive Index: 1.567
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 6-Chloro-4-methoxynicotinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloro-4-methoxynicotinic acid(716362-10-6)
• EPA Substance Registry System: 6-Chloro-4-methoxynicotinic acid(716362-10-6)

Safety Data

• Safety Statements: 24/25
• HazardClass: IRRITANT
• Hazardous Substances Data: 716362-10-6(Hazardous Substances Data)

Usage

Description

6-Chloro-4-methoxynicotinic acid is an organic compound with the molecular formula C7H6ClNO3. It is a key intermediate in the synthesis of various pharmaceutical compounds, particularly those with potential applications in the treatment of HIV infection.

Uses

Used in Pharmaceutical Industry:
6-Chloro-4-methoxynicotinic acid is used as a key intermediate for the preparation of benzimidazolylazabicyclooctylethylpiperidines. These compounds serve as Ccr5 antagonists, which play a crucial role in the treatment of HIV infection. By targeting the Ccr5 receptor, these antagonists can inhibit the entry of the HIV virus into host cells, thus helping to control the progression of the disease.

InChI:InChI=1/C7H6ClNO3/c1-12-5-2-6(8)9-3-4(5)7(10)11/h2-3H,1H3,(H,10,11)

Upstream product

• 67-56-1 methanol 
• 73027-79-9 4,6-dichloro-nicotinic acid 
• 1830-54-2 3-oxopentanedioic acid dimethyl ester 
• 79398-27-9 methyl 4,6-dihydroxypyridine-3-carboxylate 
• 84332-02-5 methyl 6-chloro-4-methoxypyridine-3-carboxylate 
• 65973-52-6 methyl 4,6-dichloropyridine-3-carboxylate 

Downstream Products

• 1609528-26-8 C₁₈H₁₆FN₅O 
• 1609528-73-5 C₁₈H₁₇FN₆O 
• 1609529-22-7 C₁₉H₁₉FN₆O₃S 

Relevant articles and documents

2-ALKOXY-6-[18F]FLUORONICOTINOYL SUBSTITUTED LYS-C(O)-GLU DERIVATIVES AS EFFICIENT PROBES FOR IMAGING OF PSMA EXPRESSING TISSUES

6-[18HF]Fluoro-2-alkoxynicotinoyl substituted Lys-C(O)-Glu derivatives were identified as efficient imaging probes for PSMA expressing tissues in comparison to other known PSMA specific ligands like [18F]DCFPyL, [68Ga]HBED-CC-PSMA, [

PYRIMIDINE TBK/IKKε INHIBITOR COMPOUNDS AND USES THEREOF

The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKKε inhibitors.

6-AMINOPYRIDIN-3-YL PYRAZOLES AS MODULATORS OF RORgT

The present invention comprises compounds of Formula I. wherein: R1, Q, R3, R4, R5, R6, A1, and A2 are defined in the specification. The invention also comprises a method of treating or ameliorating a ROR-γ-t mediated syndrome, disorder or disease, including wherein the syndrome, disorder or disease is selected from the group consisting of rheumatoid arthritis, psoriatic arthritis, and psoriasis. The invention also comprises a method of modulating RORγt activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula I.