71993-33-4Relevant articles and documents
One-pot synthesis of 3-haloflavones from flavones using Oxone and potassium halide as a halogenation reagent
Peng, Tao,Wang, Gang,Zhang, Shouguo,Sun, Yunbo,Liu, Shuchen,Wang, Lin
supporting information, (2019/12/27)
A two-step, one-pot method has been developed for the synthesis of 3-haloflavones from the corresponding flavones. The method uses Oxone and potassium halide to produce the active molecular halogen in situ. The solvent (methanol) then participates in the reaction to afford the 2-methoxy-3-haloflavanone derivative. After adding sodium hydroxide, the corresponding 3-haloflavone product is obtained in good to excellent yields. This method provides a convenient synthesis of 3-chloro, 3-bromo and 3-iodo flavones from the same flavone starting material.
Selective halogenation of 1-(2-hydroxyphenyl)-3-phenylpropane-1,3-diones using phase transfer catalysis and synthesis of 3-chloro- and 3-bromo-flavones
Makrandi,Shashi,Kumar, Surender
, p. 895 - 896 (2007/10/03)
Selective chlorination and bromination of 1-(2-hydroxyphenyl)-3-phenylpropane-1,3-diones have been achieved by their reaction with ammonium chloride/ammonium bromide and hydrogen peroxide in biphase medium using phase transfer catalysis.
A facile preparation of 3-haloflavones using hypervalent iodine* chemistry
Ho Sik Rho,Ko,Ju
, p. 2101 - 2106 (2007/10/03)
Various 3-haloflavones were prepared by the reaction of the corresponding flavone derivatives with iodobenzene diacetate and trimethylsilyl halide under mild reaction conditions. The iodobenzene diacetate could be replaced by the polymer-supported iodoben