72045-17-1 Usage
Description
1-(2-deoxypentofuranosyl)-5-(2-phenylethenyl)pyrimidine-2,4(1H,3H)-dione is a chemical compound that consists of a deoxyribose sugar molecule attached to a pyrimidine base with a phenylethyl group. 1-(2-deoxypentofuranosyl)-5-(2-phenylethenyl)pyrimidine-2,4(1H,3H)-dione is an analogue of nucleosides, which are the building blocks of nucleic acids like DNA and RNA. The presence of both the deoxyribose sugar and the pyrimidine base in the molecule suggests potential biological and pharmacological applications.
Uses
Used in Pharmaceutical Industry:
1-(2-deoxypentofuranosyl)-5-(2-phenylethenyl)pyrimidine-2,4(1H,3H)-dione is used as a potential therapeutic agent for various diseases due to its structural similarity with the building blocks of DNA and RNA. 1-(2-deoxypentofuranosyl)-5-(2-phenylethenyl)pyrimidine-2,4(1H,3H)-dione's ability to interact with nucleic acids may offer opportunities for the development of new drugs targeting genetic disorders or other conditions related to nucleic acid dysfunction.
Used in Research and Development:
In the field of molecular biology and biochemistry, 1-(2-deoxypentofuranosyl)-5-(2-phenylethenyl)pyrimidine-2,4(1H,3H)-dione can be used as a research tool to study the interactions between nucleic acids and other molecules. This may lead to a better understanding of the mechanisms underlying various biological processes and the development of novel therapeutic strategies.
Used in Drug Delivery Systems:
Similar to gallotannin, 1-(2-deoxypentofuranosyl)-5-(2-phenylethenyl)pyrimidine-2,4(1H,3H)-dione could be employed in the development of drug delivery systems to improve the bioavailability and therapeutic outcomes of certain drugs. 1-(2-deoxypentofuranosyl)-5-(2-phenylethenyl)pyrimidine-2,4(1H,3H)-dione's interaction with nucleic acids may allow for targeted delivery to specific cells or tissues, enhancing the efficacy of the treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 72045-17-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,0,4 and 5 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 72045-17:
(7*7)+(6*2)+(5*0)+(4*4)+(3*5)+(2*1)+(1*7)=101
101 % 10 = 1
So 72045-17-1 is a valid CAS Registry Number.
72045-17-1Relevant articles and documents
Water-Soluble Pd-Imidate Complexes: Broadly Applicable Catalysts for the Synthesis of Chemically Modified Nucleosides via Pd-Catalyzed Cross-Coupling
Gayakhe, Vijay,Ardhapure, Ajaykumar,Kapdi, Anant R.,Sanghvi, Yogesh S.,Serrano, Jose Luis,García, Luis,Pérez, Jose,García, Joaquím,Sánchez, Gregorio,Fischer, Christian,Schulzke, Carola
, p. 2713 - 2729 (2016/04/26)
(Figure Presented) A broadly applicable catalyst system consisting of water-soluble Pd-imidate complexes has been enployed for the Suzuki-Miyaura cross-coupling of four different nucleosides in water under mild conditions. The efficient nature of the catalyst system also allowed its application in developing a microwave-assisted protocol with the purpose of expediting the catalytic reaction. Preliminary mechanistic studies, assisted by catalyst poison tests and stoichiometric tests performed using an electrospray ionization spectrometer, revealed the possible presence of a homotopic catalyst system.
Synthesis of 5-substituted pyrimidine nucleosides through a palladium-catalyzed cross-coupling of alkenylhalosilanes
Matsuhashi, Hayao,Hatanaka, Yasuo,Kuroboshi, Manabu,Hiyama, Tamejiro
, p. 375 - 384 (2007/10/02)
Palladium-catalyzed cross-coupling of alkenylhalosilanes with 5-iodouracil and 5-iodouridine derivatives was described. 5-Iodo-1,3-dimethyluracil coupled with alkenylfluorodimethylsilanes to give the corresponding cross-coupled products in good yield. Ful
A Simple Synthesis of 5-(1-Alkenyl)uracil Derivatives by Palladium-Catalyzed Oxidative Coupling of Uracils With Olefins
Hirota, Kosaku,Isobe, Yoshiaki,Kitade, Yukio,Maki, Yoshifumi
, p. 495 - 496 (2007/10/02)
The oxidative coupling of uracil derivatives 1 with olefins, such as methyl acrylate, acrylonitrile, methyl vinyl ketone, and styrene, using one equivalent of palladium acetate leads to the corresponding 5-(1-alkenyl)uracil derivatives 2.
