72078-82-1 Usage
Description
N-METHYL-2-NITROACETAMIDE, also known as N-Methylnitroacetamide, is a chemical compound that serves as a degradation product of Ranitidine (R120000). It is commonly used in various applications across different industries, primarily due to its association with Ranitidine.
Uses
Used in Pharmaceutical Industry:
N-METHYL-2-NITROACETAMIDE is used as a degradation product for [application reason] in the pharmaceutical industry. It is utilized in the development and testing of Ranitidine, a medication used for treating conditions like peptic ulcers and gastroesophageal reflux disease (GERD). Its presence helps in understanding the stability and quality control of Ranitidine formulations.
Used in Research and Development:
N-METHYL-2-NITROACETAMIDE-d3 is used as a labeled degradation product for [application reason] in research and development. The labeled compound aids scientists in tracing and analyzing the degradation pathways of Ranitidine, providing valuable insights into the compound's stability and potential impurities.
Used in Quality Control and Impurity Profiling:
N-METHYL-2-NITROACETAMIDE (Ranitidine EP Impurity H) is used as a degradation product for [application reason] in quality control and impurity profiling. It helps ensure the safety and efficacy of Ranitidine by identifying and monitoring the presence of impurities in the final product, adhering to regulatory standards.
Check Digit Verification of cas no
The CAS Registry Mumber 72078-82-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,2,0,7 and 8 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 72078-82:
(7*7)+(6*2)+(5*0)+(4*7)+(3*8)+(2*8)+(1*2)=131
131 % 10 = 1
So 72078-82-1 is a valid CAS Registry Number.
72078-82-1Relevant articles and documents
Ring Transformation of 1,4 (or 1,6)-Disubstituted 3,5-Dinitro-2-pyridones with Sodio β-Keto Esters
Ariga, Masahiro,Tohda, Yasuo,Matsumura, Eizo
, p. 393 - 394 (1985)
The ring transformation of 1,6-dimethyl-, 1,4-dimethyl- and 4-methoxy-1-methyl-3,5-dinitro-2-pyridones with sodio β-keto esters to nitrosalicylic esters was investigated concerning the electronic effects of 4 and 6-substitutents.The results were explained by the HSAB principle.
Nucleophilic reaction upon electron-deficient pyridone derivtives. X. One-pot synthesis of 3-nitropyridines by ring transformation of 1-methyl-3,5-dinitro-2-pyridone with ketones or aldehydes in the presence of ammonia
Tohda,Eiraku,Nakagawa,Usami,Ariga,Kawashima,Tani,Watanabe,Mori
, p. 2820 - 2827 (2007/10/02)
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Pyrimidine Derivatives and Related Compounds. Part 48. Uracil Ring Transformation: Conversion of 5-Nitrouracils into 5-Carbamoyluracils
Hirota, Kosaku,Kitade, Yukio,Senda, Shigeo
, p. 1859 - 1861 (2007/10/02)
1,3-Disubstituted 5-nitrouracils (1) react with malonamide in ethanolic sodium ethoxide to afford 1-substituted 5-carbamoyluracils (3) via rearrangement of the N(3)-C(4)-C(5) portion of the uracil.This ring transformation has been applied to the preparation of 2',3',5'-tri-O-acetyl-5-carbamoyluridine (8).
