72093-41-5

Basic information

• Product Name: 1,1'-Biphenyl, 2-fluoro-4'-methyl-
• CAS NO: 72093-41-5
• Molecular Formula: C13H11F
• Molecular Weight: 186.229
• Mol File: 72093-41-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1,1'-Biphenyl, 2-fluoro-4'-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1'-Biphenyl, 2-fluoro-4'-methyl-(72093-41-5)
• EPA Substance Registry System: 1,1'-Biphenyl, 2-fluoro-4'-methyl-(72093-41-5)

Safety Data

• Hazardous Substances Data: 72093-41-5(Hazardous Substances Data)

Usage

Structure

Biphenyl derivative with a fluorine atom at the 2 position and a methyl group at the 4' position

Usage

Building block in organic synthesis and pharmaceutical research

Properties

Unique structural and electronic properties

Applications

Development of new drugs and materials

Role

Precursor in the synthesis of other organic compounds

Utility

Valuable tool for chemists and researchers in various fields

Upstream product

• 462-06-6 fluorobenzene 
• 106-38-7 para-bromotoluene 
• 71-43-2 benzene 
• 694-80-4 2-bromo-1-chlorobenzene 
• 1072-85-1 o-fluorobromobenzene 

Downstream Products

• 365-12-8 2'-fluorobiphenyl-4-carboxylic acid 
• 193013-76-2 2-fluoro-4'-bromomethylbiphenyl 

Relevant articles and documents

Ligand-Promoted Direct C-H Arylation of Simple Arenes: Evidence for a Cooperative Bimetallic Mechanism

A highly efficient catalyst for the direct C-H arylation of simple arenes was developed on the basis of a palladium-diimine complex. The developed catalyst exhibited the highest turnover number reported to date for the direct arylation of benzene due to increased stability provided by the diimine ligand. The reaction was also performed using only 2-3 equiv of simple arenes. Mechanistic studies in combination with kinetic measurements, isotope effect experiments, synthesis of possible intermediates, and stoichiometric reactions suggested that this reaction follows a cooperative bimetallic mechanism.

A new and practical grignard-coupling-fluorination sequence: Synthesis of 2-aryl fluoroarenes

A new strategy for the synthesis of 2-aryl-and 2-heteroaryl fluoroarenes has been developed. An intermolecular domino Grignard-coupling-fluorination sequence affords a range of 2-fluorobiaryls from aryl bromides under mild conditions. This methodology can be further extended to the synthesis of 2′-aryl-2-fluorobiphenyls.