7218-04-4

Basic information

• Product Name: N-acetyl-DL-cysteine
• Synonyms: N-acetyl-DL-cysteine;Cysteine, N-acetyl-;Cysteine, N-acetyl-, DL- (8CI);DL-Cysteine, N-acetyl-;2-Acetamido-3-mercaptopropanoic acid;2-Acetamido-3-sulfanylpropanoic acid
• CAS NO: 7218-04-4
• Molecular Formula: C₅H₉NO₃S
• Molecular Weight: 163.19486
• EINECS: 230-609-9
• Mol File: 7218-04-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 407.678 °C at 760 mmHg
• Flash Point: 200.357 °C
• Appearance: /
• Density: 1.295 g/cm³
• Vapor Pressure: 8.68E-08mmHg at 25°C
• Refractive Index: 1.518
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Aqueous Base (Slightly), Chloroform (Slightly, Heated, Sonicated), DMSO (Slightl
• PKA: 3.25±0.10(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: N-acetyl-DL-cysteine(CAS DataBase Reference)
• NIST Chemistry Reference: N-acetyl-DL-cysteine(7218-04-4)
• EPA Substance Registry System: N-acetyl-DL-cysteine(7218-04-4)

Safety Data

• Hazardous Substances Data: 7218-04-4(Hazardous Substances Data)

Usage

Description

N-acetyl-DL-cysteine, also known as NAC, is a modified form of the amino acid cysteine. It is an antioxidant and a precursor to the antioxidant glutathione, which plays a crucial role in the body's detoxification processes. NAC has various applications in different industries due to its unique properties and potential health benefits.

Uses

Used in Pharmaceutical Industry:
N-acetyl-DL-cysteine is used as a reagent for the synthesis of phenylalkyl isoselenocyanates, which have demonstrated anticancer activity. This application highlights NAC's role in the development of potential cancer treatments and its contribution to the pharmaceutical industry.
Used in Antioxidant and Detoxification:
NAC is used as a supplement to support the body's natural antioxidant and detoxification processes. It helps maintain the balance of glutathione, which is essential for neutralizing harmful free radicals and toxins in the body.
Used in Respiratory Health:
N-acetyl-DL-cysteine is used to support respiratory health, particularly in conditions like chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Its mucolytic properties help break down and clear mucus from the airways, improving lung function and overall respiratory health.
Used in Liver Health:
NAC is used to support liver health by aiding in the detoxification process and protecting liver cells from damage. It has been shown to be beneficial in the treatment of acetaminophen overdose and certain liver diseases.
Used in Skin Care:
In the cosmetic industry, N-acetyl-DL-cysteine is used as an ingredient in skincare products for its antioxidant and anti-aging properties. It helps protect the skin from environmental damage and supports the skin's natural repair processes.

InChI:InChI=1/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9)/t4-/m0/s1

Upstream product

• 19538-71-7 N-acetyl-S-benzyl-D,L-cysteine 
• 60-24-2 2-hydroxyethanethiol 
• 118456-64-7 ethyl N-acetyl-S-benzyl-D,L-cysteinate 

Downstream Products

• 7652-46-2 2-acetylamino-3-mercapto-propionic acid methyl ester 
• 15139-21-6 5-thio-2-nitrobenzoic acid 
• 103-90-2 4-acetaminophenol 
• 60603-13-6 2-acetamido-3-(5′-acetamido-2′-hydroxyphenylthio) propanoic acid 
• 75-66-1 2-methylpropan-2-thiol 
• 60-24-2 2-hydroxyethanethiol 
• 75-08-1 ethanethiol 
• 75-33-2 2-propanethiol 
• 2935-90-2 Methyl 3-mercaptopropionate 
• 6258-66-8 (4-chlorophenyl)methanethiol 
• 52-90-4 L-Cysteine 
• 26117-28-2 (S)-N-acetylcysteine 
• 921-01-7 rac-cysteine 
• 56-89-3 cysteine disulfide 

Relevant articles and documents

Combination Therapies for Treating Metabolic Disorders

This invention is directed to pharmaceutical combinations comprising an antioxidant agent, an anti-inflammatory agent, and optionally at least one other anti-diabetic agent useful for treating metabolic disorders. This invention also encompasses pharmaceutically acceptable compositions comprising an antioxidant agent, an anti-inflammatory agent, optionally at least one other anti-diabetic agent, and at least one pharmaceutically acceptable carrier. The combinations and compositions of this invention are useful as methods for treating metabolic disorders including diabetes, particularly Type I and Type II diabetes, as well as diseases and disorders associated with diabetes, including but not limited to atherosclerosis, cardiovascular disease, inflammatory disorders, nephropathy, neuropathy, retinopathy, β-cell dysfunction, dyslipidemia, LADA, metabolic syndrome, hyperglycemia, insulin resistance, and/or chronic obstructive pulmonary disease in a mammal, particularly a diabetic mammal, and specifically a human patient. This invention is particularly directed to pharmaceutical compositions comprising an lipoic acid, one or more anti-inflammatories selected from the group consisting of diflunisal, diclofenac, dexibuprofen, dexketoprofen, naproxen, and salicylate, and optionally one or more pharmaceutically acceptable carriers. The compositions of this invention are useful as methods for treating metabolic disorders including type II diabetes, insulin resistance, beta-cell dysfunction, and hyperglycemia in a patient, particularly a diabetic patient.

Liver function improvement formulation

A food supplement formulation effective to improve the function of the liver comprises selenium, milk thistle seed, phosphatidyl choline, dandelion root, l-methionine, l-taurine, N-acetyl-cysteine, alpha lipoic arid, artichoke leaf, green tea leaf, turmeric root, belleric myrobalan fruit, boerhavia diffusa, eclipta alba, wedelolactones tinospora cordifolia, andrographis paniculata, and picrorhiza kurroa.

Reactivity of sulfur nucleophiles towards S-nitrosothiols

Rate constants have been measured for the reactions of a range of S-nitrosothiols with the following sulfur-centred nucleophiles: sulfite ion, thiourea, thiocyanate ion, thiosulfate ion, thiomethoxide ion and sulfide ion. Many of the reactions were very fast and were followed in a stopped-flow spectrophotometer. For the sulfite reaction the reactive species over the pH range 4-8 was shown to be exclusively SO32-. For two RSNO species the reactivity sequence was established as: SO32- > MeS- > S2O32- ? SC(NH2)2 SCN-. The reaction with sulfide ion was also rapid and generated a fairly stable yellow species (λmax 410 nm), which was probably the nitrosodisulfide ion ONSS-, but the absorbance-time data were too complex for a simple kinetic analysis. This reaction could have some potential as an analytical procedure for the determination of RSNO species. The kinetic results are discussed in terms of the factors affecting nucleophilicity and are compared with the corresponding reactions of other nitrosating species.