72216-04-7

Basic information

• Product Name: 2-(2-Fluorophenyl)pyrrolidine
• Synonyms: 2-(2-FLUOROPHENYL)PYRROLIDINE
• CAS NO: 72216-04-7
• Molecular Formula: C₁₀H₁₂FN
• Molecular Weight: 165.21
• Product Categories: Benzenes
• Mol File: 72216-04-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 219 °C at 760 mmHg
• Flash Point: 86.2 °C
• Appearance: Colorless/Liquid
• Density: 1.078 g/cm³
• Vapor Pressure: 0.0887mmHg at 25°C
• Refractive Index: 1.515
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 9.37±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• Stability: Hygroscopic
• CAS DataBase Reference: 2-(2-Fluorophenyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Fluorophenyl)pyrrolidine(72216-04-7)
• EPA Substance Registry System: 2-(2-Fluorophenyl)pyrrolidine(72216-04-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 72216-04-7(Hazardous Substances Data)

Usage

Uses

2-(2-Fluorophenyl)pyrrolidine is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.

InChI:InChI=1/C10H12FN/c11-10-4-2-1-3-9(10)8-5-6-12-7-8/h1-4,8,12H,5-7H2

Relevant articles and documents

Stereocomplementary Synthesis of Pharmaceutically Relevant Chiral 2-Aryl-Substituted Pyrrolidines Using Imine Reductases

Exploring a collection of naturally occurring imine reductases (IREDs) identified two stereocomplementary IREDs with reducing activity toward sterically hindered 2-aryl-substituted pyrrolines. Using (R)-selective ScIR and (S)-selective SvIR, various chiral 2-aryl-substituted pyrrolidines with excellent enantioselectivity (>99% ee) were stereocomplementarily synthesized in good yield (60-80%), demonstrating the feasibility of IREDs for generating pharmaceutically relevant chiral 2-aryl-substituted pyrrolidine intermediates.