72229-32-4Relevant articles and documents
New and concise approach to (R)-α-lipoic acid
Wei, Zhen,Lan, Hong-Qiao,Zheng, Jian-Feng,Huang, Pei-Qiang
experimental part, p. 691 - 701 (2009/07/18)
A concise enantiospecific synthesis of (S)-6,8-bis(methylsulfonyloxy)- octanoic acid (2), a ready precursor of (R)-(+)-α-lipoic acid (1), is reported. The key step of the synthesis is the coupling of the tosylate derived from (R)-malic acid with phenylpro