72287-76-4Relevant articles and documents
FT-IR Spectrometric Study of N-t-Butoxycarbonylglycine N',N'-dimethylamide and its Interaction with Proton Donors
Parmentier, J.,Samyn, C.,Beylen, M. Van,Zeegers-Huyskens, Th.
, p. 387 - 392 (1991)
FT-IR spectra of N-t-butoxycarbonylglycine-N',N'-dimethylamide and its deuteriated ND counterpart, in solution and in the solid state, have been analysed between 3800 and 400 cm-1.An assignment is proposed for some important vibrations, especially for the so-called amide vibrations, by comparison with literature data on similar molecules.The frequency shifts and intensity changes of the vibrations sensitive to the physical state of this model dipeptide strongly suggest that intermolecular hydrogen bonds involving mainly the NH and C=O (amide) groups are formed in the solid state.Thermodynamic parameters (equilibrium constants and enthalpies) of the hydrogen-bond formation with phenol derivatives have been determined in carbon tetrachloride and in 1,2-dichloroethane.The complexes investigated are of medium strength.The FT-IR spectra in the νC=O region and the double perturbation of the νNH band assigned to the five-membered intramolecular NH...O=C hydrogen-bonded ring clearly show that complex formation occurs at both the amide and urethane carbonyl groups.About 45percent of the complexes are formed on the C=O (urethane) function, almost independent of the acidity of the phenols.The unusual broadness of the OH...O=C complex band originates from the superposition of two complex bands.N-t-Butoxycarbonylglycine-N',N'-dimethylamide can be considered as being built up from two model molecules, methyl-N-methylcarbamate and N,N-dimethylacetamide.
Highly Selective and Sensitive Detection of Biogenic Defense Phytohormone Salicylic Acid in Living Cells and Plants Using a Novel and Viable Rhodamine-Functionalized Fluorescent Probe
Fu, Yi-Hong,Li, Wen,Li, Zhong,Ouyang, Gui-Ping,Wang, Pei-Yi,Wang, Zhen-Chao,Wen, Xiao-Peng,Yang, Lin-Lin,Yang, Song,Zou, Si-Yan
, p. 4285 - 4291 (2020/05/14)
Detecting plant-derived signal molecules using fluorescent probes is a key topic and a huge challenge for scientists. Salicylic acid (SA), a vital plant-derived defense hormone, can activate global transcriptional reprogramming to systemically express a network of prominent pathogenesis-related proteins against invasive microorganisms. This strategy is called systemic acquired resistance (SAR). Therefore, monitoring the dynamic fluctuations of SA in subcellular microenvironments can advance our understanding of different physiological and pathological functions during the SA-induced SAR mechanism, thus benefiting the discovery and development of novel immune activators that contribute to crop protection. Here, detection of signaling molecule SA in plant callus tissues was first reported and conducted by a simple non-fluorescent rhodamine-tagged architecture bearing a flexible 2-amino-N,N-dimethylacetamide pattern. This study can markedly advance and promote the usage of fluorescent SA probes for distinguishing SA in the plant kingdom.
Structural studies of β-turn-containing peptide catalysts for atroposelective quinazolinone bromination
Metrano,Abascal,Mercado,Paulson,Miller
supporting information, p. 4816 - 4819 (2016/04/09)
We describe herein a crystallographic and NMR study of the secondary structural attributes of a β-turn-containing tetra-peptide, Boc-Dmaa-d-Pro-Acpc-Leu-NMe2, which was recently reported as a highly effective catalyst in the atroposelective bromination of 3-arylquinazolin-4(3H)-ones. Inquiries pertaining to the functional consequences of residue substitutions led to the discovery of a more selective catalyst, Boc-Dmaa-d-Pro-Acpc-Leu-OMe, the structure of which was also explored. This new lead catalyst was found to exhibit a type I′ β-turn secondary structure both in the solid state and in solution, a structure that was shown to be an accessible conformation of the previously reported catalyst, as well.