7230-41-3

Basic information

• Product Name: 1-(5-nitropyridin-2-yl)pyrrolidine-2-carboxylic acid
• Synonyms: 1-(5-nitropyridin-2-yl)pyrrolidine-2-carboxylic acid
• CAS NO: 7230-41-3
• Molecular Formula: C₁₃H₁₂FNO₂S
• Molecular Weight: 237.212
• Mol File: 7230-41-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 500.9°C at 760 mmHg
• Flash Point: 256.7°C
• Appearance: /
• Density: 1.47g/cm³
• Vapor Pressure: 7.5E-11mmHg at 25°C
• Refractive Index: 1.627
• CAS DataBase Reference: 1-(5-nitropyridin-2-yl)pyrrolidine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-nitropyridin-2-yl)pyrrolidine-2-carboxylic acid(7230-41-3)
• EPA Substance Registry System: 1-(5-nitropyridin-2-yl)pyrrolidine-2-carboxylic acid(7230-41-3)

Safety Data

• Hazardous Substances Data: 7230-41-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H11N3O4/c14-10(15)8-2-1-5-12(8)9-4-3-7(6-11-9)13(16)17/h3-4,6,8H,1-2,5H2,(H,14,15)

Upstream product

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Downstream Products

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Relevant articles and documents

Metal-free one-pot synthesis of N-arylsulfonamides from nitroarenes and sodium sulfinates in an aqueous medium

A metal-free one-pot two-step synthesis of sulfonamides from readily available nitroarenes and sodium arylsulfinates in a mixture of methanol and water has been developed. In this procedure, the aryl amines were produced in situ by the reduction of nitroarenes mediated by diboronic acid, and then coupled with sodium arylsulfinates in the presence of iodine. A series of N-arylsulfonamides with various functional groups were obtained in moderate to good yields under the optimal reaction conditions. In addition, this one-pot process is applicable for gram-scale synthesis.

Synthesis of N -Arylsulfonamides by a Copper-Catalyzed Reaction of Chloramine-T and Arylboronic Acids at Room Temperature

A copper-catalyzed Chan-Lam-coupling-like reaction of a (het)arylboronic acid and chloramine-T (or a related compound) has been developed for the synthesis of N -arylsulfonamides at room temperature in moderate to good yields, with good tolerance of functional groups. In this process, it is believed that chloramine-T serves as an electrophile.

Copper-catalyzed cross-coupling of chloramine salts and arylboronic acids in water: A green and practical route to N-arylsulfonamides

A green and practical method for the synthesis of N-arylsulfonamides from chloramine salts and arylboronic acids is herein developed. The reaction proceeds readily in the presence of 5 mol% of CuI and 2.5 equiv. K2CO3 in water at room temperature, generating a variety of N-arylsulfonamides in moderate to good yields with good functional group tolerance.