72373-81-0

Basic information

• Product Name: METHYL 2-FLUORO-6-HYDROXYBENZOATE
• Synonyms: RARECHEM AL BF 1190;METHYL 2-FLUORO-6-HYDROXYBENZOATE;METHYL 6-FLUORO-2-HYDROXYBENZOATE;METHYL 6-FLUOROSALICYLATE;2-FLUORO-6-HYDROXY-BENZOIC ACID METHYL ESTER;Methyl 6-fluorosalicylate, 3-Fluoro-2-(methoxycarbonyl)phenol
• CAS NO: 72373-81-0
• Molecular Formula: C₈H₇FO₃
• Molecular Weight: 170.14
• Product Categories: Benzoic acid
• Mol File: 72373-81-0.mol
• Article Data: 8

Chemical Properties

• Melting Point: 71°C
• Boiling Point: 65-70°C 1,7mm
• Flash Point: 96.1 °C
• Appearance: /
• Density: 1.309 g/cm³
• Vapor Pressure: 0.0328mmHg at 25°C
• Refractive Index: 1.526
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: METHYL 2-FLUORO-6-HYDROXYBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-FLUORO-6-HYDROXYBENZOATE(72373-81-0)
• EPA Substance Registry System: METHYL 2-FLUORO-6-HYDROXYBENZOATE(72373-81-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 72373-81-0(Hazardous Substances Data)

Usage

General Description

Methyl 2-fluoro-6-hydroxybenzoate is a chemical compound with the molecular formula C8H7FO3. It is an ester derivative of 2-fluoro-6-hydroxybenzoic acid and is commonly used in the pharmaceutical and chemical industries. METHYL 2-FLUORO-6-HYDROXYBENZOATE is known for its potential as a building block in the synthesis of various pharmaceuticals and natural products. It is also used in the production of fragrances and flavorings due to its aromatic properties. Methyl 2-fluoro-6-hydroxybenzoate is considered to be relatively stable and has low toxicity, making it a valuable and versatile compound in the field of organic chemistry.

InChI:InChI=1/C8H7FO3/c1-12-8(11)7-5(9)3-2-4-6(7)10/h2-4,10H,1H3

Upstream product

• 67-56-1 methanol 
• 67531-86-6 6-fluorosalicylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 

Downstream Products

• 960249-93-8 methyl 2-[(difluoromethyl)oxy]-6-fluorobenzoate 
• 799262-09-2 5-fluoro-4-hydroxycoumarin 
• 1224594-78-8 C₁₄H₁₇FO₅ 
• 178747-83-6 4-fluoro-benzo[d]isoxazol-3-ol 
• 1331782-39-8 (R)-3-(piperidin-4-ylmethoxy)-4-(tetrahydrofuran-3-yloxy)benzo[d]isoxazole 4-methylbenzenesulfonate 
• 855996-64-4 2-fluoro-N,6-dihydroxybenzamide 
• 108-95-2 phenol 

Relevant articles and documents

WDR5-MYC INHIBITORS

Substituted N-phenyl sulfonamide compounds inhibit WDR5-MYC interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.

Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction

The treatment of tumors driven by overexpression or amplification of MYC oncogenes remains a significant challenge in drug discovery. Here, we present a new strategy toward the inhibition of MYC via the disruption of the protein-protein interaction betwee

Two Routes to 4-Fluorobenzisoxazol-3-one in the Synthesis of a 5-HT4 Partial Agonist

A potent 5-HT4 partial agonist, 1 (PF-04995274), targeted for the treatment of Alzheimer's disease and cognitive impairment, has been prepared on a multi-kilogram scale. The initial synthetic route, that proceeded through a 4-substituted 3-hydroxybenzisoxazole core, gave an undesired benzoxazolinone through a Lossen-type rearrangement. Route scouting led to two new robust routes to the desired 4-substituted core. Process development led to the efficient assembly of the API on a pilot plant scale under process-friendly conditions with enhanced throughput. In addition, crystallization of a hemicitrate salt of the API with pharmaceutically beneficial properties was developed to enable progression of clinical studies.