725-67-7

Basic information

• Product Name: (2S)-3-Methyl-2-[(phenylmethyl)carbonyl]aminobutyric acid
• Synonyms: (2S)-3-Methyl-2-[(phenylmethyl)carbonyl]aminobutyric acid
• CAS NO: 725-67-7
• Molecular Weight: 235.283
• Mol File: 725-67-7.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: (2S)-3-Methyl-2-[(phenylmethyl)carbonyl]aminobutyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-3-Methyl-2-[(phenylmethyl)carbonyl]aminobutyric acid(725-67-7)
• EPA Substance Registry System: (2S)-3-Methyl-2-[(phenylmethyl)carbonyl]aminobutyric acid(725-67-7)

Safety Data

• Hazardous Substances Data: 725-67-7(Hazardous Substances Data)

Upstream product

• 516-06-3 D,L-valine 
• 103-80-0 phenylacetyl chloride 
• 103-82-2 phenylacetic acid 
• 72-18-4 L-valine 
• 6125-24-2 2-Phenylnitroethane 
• 101-41-7 benzeneacetic acid methyl ester 
• 2752-50-3 N-phenylacetylvaline 

Relevant articles and documents

N-Phenylacetylation and Nonribosomal Peptide Synthetases with Substrate Promiscuity for Biosynthesis of Heptapeptide Variants, JBIR-78 and JBIR-95

JBIR-78 (1) and JBIR-95 (2), both of which are heptapeptide derivatives isolated from Kibdelosporangium sp. AK-AA56, have the same amino acid sequences except for the second amino acid: phenylacetic acid (Paa)-l-Val-d-Asp (1)/d-cysteic acid (2)-l-Ala-(3S)-3-hydroxy-d-Leu-Gly-d-Ala-l-Phe. Heterologous expression of the biosynthetic gene cluster including genes encoding nonribosomal peptide synthetases (NRPS) and in vitro assays with recombinant Orf3, an l-cysteic acid synthase homologue, suggested the single A domain in module 2 activates both l-Asp and l-cysteic acid to yield 1 and 2, respectively, although the substrate specificities of the A domains of NRPSs are usually strict. Biosynthetic mechanism of introduction of N-terminal Paa was also investigated. Recombinant Orf1 and Orf2 similar to subunits of pyruvate dehydrogenase complex catalyzed the conversion of phenylpyruvate into phenylacetyl-CoA together with dihydrolipoyl dehydrogenase whose encoding gene is located outside of the gene cluster. Moreover, we showed that phenylacetyl-CoA was directly condensed with l-Val, which was tethered to a peptidyl carrier protein, at the first condensation domain in the NRPS.

AZAINDOLINE COMPOUNDS AS GRANZYME B INHIBITORS

Azaindoline compounds as granzyme B inhibitors, compositions that include the compounds, and methods for using the compounds. Methods for treating cutaneous scleroderma, epidermolysis bullosa, radiation dermatitis, alopecia areata, and discoid lupus erythematosus are provided.

COSMETIC USES AND METHODS FOR INDOLINE GRANZYME B INHIBITOR COMPOSITIONS

Cosmetic uses and methods for indoline granzyme B inhibitor compounds in compositions with a cosmetically acceptable carrier. Uses and methods for treating, reducing or inhibiting the appearance of ageing in the skin are provided. Also provided are compositions and formulation for cosmetic uses and methods of maintaining a youthful appearance, reducing an appearance of ageing, inhibiting an appearance of ageing, reducing a rate of an appearance of ageing, reducing a skin inelasticity, reducing a rate of increasing skin inelasticity, maintaining a skin elasticity, and increasing the density of hair follicles of a skin of a subjecl. The uses and methods comprise applying/administering an indoline granzyme B inhibitor to a skin, or a portion of a skin of the subject.