7253-19-2 Usage
Description
5'-O-(4-METHYLPHENYLSULPHONYL)THYMIDINE is a nucleoside analogue that functions as an inhibitor of thymidylate kinases, which are enzymes involved in the synthesis of DNA. 5'-O-(4-METHYLPHENYLSULPHONYL)THYMIDINE plays a significant role in the regulation of DNA replication and repair processes.
Uses
Used in Pharmaceutical Industry:
5'-O-(4-METHYLPHENYLSULPHONYL)THYMIDINE is used as a pharmaceutical agent for its ability to inhibit thymidylate kinases. This inhibition can lead to the suppression of DNA synthesis and replication, making it a potential candidate for the development of antiviral and anticancer therapies.
Used in Antiviral Applications:
As a nucleoside analogue, 5'-O-(4-METHYLPHENYLSULPHONYL)THYMIDINE is used as an antiviral agent to target and inhibit the activity of thymidylate kinases in viral replication. This can help control viral infections and limit the spread of the virus within the host.
Used in Anticancer Applications:
5'-O-(4-METHYLPHENYLSULPHONYL)THYMIDINE is used as an anticancer agent due to its ability to interfere with the activity of thymidylate kinases, which are essential for DNA synthesis and replication in cancer cells. By inhibiting these enzymes, the compound can potentially slow down or stop the growth and proliferation of cancerous cells.
Used in Research and Development:
5'-O-(4-METHYLPHENYLSULPHONYL)THYMIDINE is also used in research and development settings to study the role of thymidylate kinases in various biological processes. This can help scientists better understand the mechanisms of DNA replication, repair, and the development of antiviral and anticancer therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 7253-19-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 7,2,5 and 3 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 7253-19:
(6*7)+(5*2)+(4*5)+(3*3)+(2*1)+(1*9)=92
92 % 10 = 2
So 7253-19-2 is a valid CAS Registry Number.
InChI:InChI=1/C17H20N2O7S/c1-10-3-5-12(6-4-10)27(23,24)25-9-14-13(20)7-15(26-14)19-8-11(2)16(21)18-17(19)22/h3-6,8,13-15,20H,7,9H2,1-2H3,(H,18,21,22)
7253-19-2Relevant articles and documents
Solid-phase synthesis and evaluation of TAR RNA targeted β-carboline-nucleoside conjugates
Zhao, Peng,Jin, Hong-Wei,Yang, Zhen-Jun,Zhang, Liang-Ren,Zhang, Li-He
scheme or table, p. 3741 - 3750 (2009/02/05)
Four types of β-carboline-nucleoside conjugates were synthesized. The binding affinities of these β-carboline-nucleoside conjugates 4-11, 13 and 15 to TAR RNA were evaluated by affinity capillary electrophoresis. The data of binding affinities to TAR RNA show that conjugates 9 and 13 are stronger binders than the parent compound MC3. Computer modeling indicates that the β-carboline-nucleoside conjugate 13 can fit to the UCU three-nucleotide bulge region of TAR RNA. The Royal Society of Chemistry 2008.
Novel diastereomeric thymidine cyclic 3',5'-threo-phosphoramidates
Katalenic, Darinka,Zinic, Mladen
, p. 1231 - 1236 (2007/10/03)
Novel diastereomeric thymidine cyclic 3',5'-threo-phosphoramidates were prepared by the treatment of 5'-azido derivative of threo-thymidine with triphenyl phosphite as well as by the treatment of the corresponding amino derivative with phenyl phosphodichloridate. Phosphoramidation of the regioisomeric 3'- and 5'-azido derivatives of erythro-thymidine by means of triphenyl phosphite afforded the open-chain 3'- and 5'-phosphoramidates. The reaction which afforded the cyclic products was assumed to proceed via the cyclic tetraoxazaphosphorane intermediates.
Novel P1,P2-substituted phosphonate analogues of 2'-deoxyadenosine and 2'-deoxythymidine 5'-triphosphates
Blackburn,Langston
, p. 6425 - 6428 (2007/10/02)
P1,P2-Substituted methylene, fluoromethylene, and difluoromethylene analogues of the deoxynucleotides 2'-deoxyadenosine 5'-triphosphate and thymidine 5'-triphosphate have been prepared by reaction between the bisphosphonic acid and t
