726181-69-7

Basic information

• Product Name: (S)-3-(4-hydroxy-3-nitrophenyl)-2-[(ethoxycarbonyl)amino]-1-propanoic acid methyl ester
• Synonyms: (S)-3-(4-hydroxy-3-nitrophenyl)-2-[(ethoxycarbonyl)amino]-1-propanoic acid methyl ester
• CAS NO: 726181-69-7
• Molecular Weight: 312.279
• Mol File: 726181-69-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (S)-3-(4-hydroxy-3-nitrophenyl)-2-[(ethoxycarbonyl)amino]-1-propanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-(4-hydroxy-3-nitrophenyl)-2-[(ethoxycarbonyl)amino]-1-propanoic acid methyl ester(726181-69-7)
• EPA Substance Registry System: (S)-3-(4-hydroxy-3-nitrophenyl)-2-[(ethoxycarbonyl)amino]-1-propanoic acid methyl ester(726181-69-7)

Safety Data

• Hazardous Substances Data: 726181-69-7(Hazardous Substances Data)

Upstream product

• 54996-28-0 3-nitro-L-tyrosinemethyl ester hydrochloride 
• 541-41-3 chloroformic acid ethyl ester 
• 60-18-4 L-tyrosine 
• 1080-06-4 L-Tyr-OMe 
• 215596-38-6 (S)-3-(4-hydroxyphenyl)-2-[(ethoxycarbonyl)amino]-1-propanoic acid methyl ester 
• 186581-53-3 diazomethane 

Downstream Products

• 726181-70-0 Fmoc-3-amino-L-tyrosine 
• 136590-09-5 (S)-3-(3-nitro-4-hydroxyphenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propionic acid 
• 621-44-3 3-nitro-L-tyrosine 

Relevant articles and documents

Rapid acidolysis of benzyl group as a suitable approach for syntheses of peptides naturally produced by oxidative stress and containing 3-nitrotyrosine

3-Nitrotyrosine (Nit) belongs to products of oxidative stress and could probably influence conformation of neurodegenerative proteins. Syntheses of peptides require availability of suitable synthon for introduction of Nit residue. Common phenolic protecti

Development of L-3-aminotyrosine suitably protected for the synthesis of a novel nonphosphorylated hexapeptide with low-nanomolar Grb2-SH2 domain-binding affinity

Synthesis of orthogonally protected (2S)-2-amino-3-(3-amino-4-hydroxy- phenyl)-propionic acid (10) suitable for solid phase peptide synthesis and its first use for the preparation of nonphosphorylated Grb2-SH2 domain antagonists (4a-c) are reported. The 3-aminotyrosine containing sulfoxide-cyclized hexapeptide (4b) exhibited potent Grb2-SH2 domain binding affinity with IC 50=50nM, which represents the highest affinity yet reported for a peptide inhibitor against Grb2-SH2 domain with only 6 residues free of phosphotyrosine or phosphotyrosine mimics. This potent small peptidomimetic 4b may be representative of a new class of therapeutically relevant Grb2-SH2 domain-directed agents, and acts as a chemotherapeutic lead for the treatment of erbB2-related cancers.