72666-54-7

Basic information

• Product Name: 3-(3,4-DIMETHOXYPHENYL)-1-(4-METHYLPHENYL)PROP-2-EN-1-ONE
• Synonyms: 3-(3,4-DIMETHOXYPHENYL)-1-(4-METHYLPHENYL)PROP-2-EN-1-ONE;3,4-DIMETHOXY-4'-METHYLCHALCONE;(2E)-3-(3,4-dimethoxyphenyl)-1-(4-methylphenyl)prop-2-en-1-one
• CAS NO: 72666-54-7
• Molecular Formula: C₁₈H₁₈O₃
• Molecular Weight: 282.33
• Mol File: 72666-54-7.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(3,4-DIMETHOXYPHENYL)-1-(4-METHYLPHENYL)PROP-2-EN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3,4-DIMETHOXYPHENYL)-1-(4-METHYLPHENYL)PROP-2-EN-1-ONE(72666-54-7)
• EPA Substance Registry System: 3-(3,4-DIMETHOXYPHENYL)-1-(4-METHYLPHENYL)PROP-2-EN-1-ONE(72666-54-7)

Safety Data

• Hazardous Substances Data: 72666-54-7(Hazardous Substances Data)

Upstream product

• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 122-00-9 para-methylacetophenone 

Downstream Products

• 72666-53-6 2-Biphenyl-4-yl-4-(3,4-dimethoxy-phenyl)-6-p-tolyl-pyridine 
• 136465-47-9 1-(4-methylphenyl)-3-(3,4-dimethoxyphenyl)propan-1-one 
• 72666-50-3 2-(4-chloro-phenyl)-4-(3,4-dimethoxy-phenyl)-6-p-tolyl-pyridine 
• 72666-42-3 4-(3,4-Dimethoxy-phenyl)-2-phenyl-6-p-tolyl-pyridine 
• 78743-72-3 [2-Benzoyl-3-(3,4-dimethoxy-phenyl)-cyclopropyl]-p-tolyl-methanone 
• 158575-07-6 2,3-dibromo-3-(3,4-dimethoxyphenyl)-1-(4-methylphenyl)-propan-1-one 
• 331980-15-5 2-Amino-4-(3,4-dimethoxy-phenyl)-6-p-tolyl-nicotinonitrile 
• 158575-11-2 3-(3,4-dimethoxyphenyl)-1-(4-methylphenyl)propan-1,3-dione 
• 136465-48-0 3-(4-methylphenyl)-5,6-dimethoxyindene 
• 136465-40-2 1-(4-methylphenyl)-5,6-dimethoxyindane 
• 136465-39-9 1-Benzyl-5,6-dimethoxy-3-p-tolyl-1H-indene 
• 136465-42-4 cis-1-benzyl-3-(4-methylphenyl)-5,6-dimethoxyindane 
• 1032469-66-1 1-thiocarbamoyl-3-(4-methylphenyl)-5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazole 
• 1197386-05-2 2-(p-tolylthio)-4-(3,4-dimethoxyphenyl)-6-p-tolylpyridine-3-carbonitrile 

Relevant articles and documents

Lewis acid catalyst system for Claisen-Schmidt reaction under solvent free condition

Ca(OTf)2 in combination with NBu4.BF4 was established to function as an efficient catalyst system for one-pot Claisen-Schmidt condensation under neat conditions. Substituted acetophenones and benzaldehydes were coupled in situ to afford their corresponding chalcones in excellent yields. The method, with a broad range of substrate tolerance and mild operational conditions can produce assorted chalcone derivatives in moderate to high yields from easily accessible starting materials.

Synthesis and biological evaluation of pyrimidine bridged combretastatin derivatives as potential anticancer agents and mechanistic studies

A number of pyrimidine bridged combretastatin derivatives were designed, synthesized and evaluated for anticancer activities against breast cancer (MCF-7) and lung cancer (A549) cell lines using MTT assays. Most of the synthesized compounds displayed good

Practical synthesis of β-isothiocyanato ketones from chalcones

Practical synthesis of 1,3-diaryl-substituted 3-isothiocyanatopropan-1-ones based on the reaction of chalcones with thiocyanic acid generated in situ by treatment of thiocyanate ammonium with dilute sulfuric acid has been developed.