727-36-6

Basic information

• Product Name: N-Benzyl-4-fluorobenzenesulfonamide
• Synonyms: N-Benzyl-4-fluorobenzenesulfonamide
• CAS NO: 727-36-6
• Molecular Formula: C₁₃H₁₂FNO₂S
• Molecular Weight: 265
• Mol File: 727-36-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 99 °C
• Boiling Point: 405.0±55.0 °C(Predicted)
• Appearance: /
• Density: 1.294±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 11.09±0.30(Predicted)
• CAS DataBase Reference: N-Benzyl-4-fluorobenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzyl-4-fluorobenzenesulfonamide(727-36-6)
• EPA Substance Registry System: N-Benzyl-4-fluorobenzenesulfonamide(727-36-6)

Safety Data

• Hazardous Substances Data: 727-36-6(Hazardous Substances Data)

Usage

Description

N-Benzyl-4-fluorobenzenesulfonamide is a chemical compound with the molecular formula C13H12FNO2S. It is a sulfonamide derivative featuring a benzyl group and a fluorine atom attached to a benzene ring. N-Benzyl-4-fluorobenzenesulfonamide has been investigated for its potential pharmaceutical properties, particularly as an inhibitor of carbonic anhydrase enzymes.

Uses

Used in Pharmaceutical Industry:
N-Benzyl-4-fluorobenzenesulfonamide is used as a carbonic anhydrase enzyme inhibitor for the treatment of conditions such as glaucoma, epilepsy, and edema. Its ability to inhibit these enzymes can help manage the symptoms and progression of these diseases.
Used in Drug Development:
N-Benzyl-4-fluorobenzenesulfonamide may also possess other biological activities, making it a candidate for the development of new drugs. Further research is required to fully understand its properties and explore additional potential applications in the pharmaceutical field.

Upstream product

• 402-46-0 4-fluorophenylsulphonamide 
• 100-51-6 benzyl alcohol 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 100-46-9 benzylamine 
• 824-80-6 sodium 4-fluorobenzenesulfinate 

Downstream Products

• 276695-39-7 N-benzyl-N-[(4-fluorophenyl)sulfonyl]glycine 
• 839690-41-4 N-benzyl-N-[(4-fluorophenyl)sulfonyl]glycine methyl ester 
• 1414850-48-8 N-benzyl-4-fluoro-N-(phenylethynyl)benzenesulfonamide 
• 186800-76-0 N-benzylidene-4-fluorobenzenesulfonamide 

Relevant articles and documents

Method for synthesizing N-alkyl sulfonamide in water

The invention discloses a method for synthesizing N-alkyl sulfonamide in water, in particular to a method for synthesizing an N-alkyl sulfonamide derivative from a sulfonamide derivative and alcohol,and a water-soluble iridium complex is adopted to catalyze the reaction of N-alkyl sulfonamide. Compared with the previous synthesis method, the method has the advantages that a reaction equivalent substrate is used in the reaction process, so that raw material waste is avoided; weak base is used, and reaction conditions are mild; non-toxic and harmless pure water is used as a solvent in the reaction, only water is generated as a by-product, the atom reaction economy is high, and the requirement of green chemistry is met.

Method for catalytic synthesis of N-benzyl benzene sulfonamide compounds by boric acid/oxalic acid catalytic system under microwave radiation

The invention discloses a method for catalytic synthesis of N-benzyl benzene sulfonamide compounds by a boric acid/oxalic acid catalytic system under microwave radiation. The method includes: adoptingbenzyl alcohol and derivatives thereof and benzene sulfonamide derivatives as raw materials, adopting the boric acid/oxalic acid system as a catalyst, and adopting fluorobenzene as a solvent; performing reaction in a microwave reactor under certain temperature and power conditions, performing vacuum concentration after reaction for a period of time, and subjecting a product to column chromatographic purification to realize efficient catalytic preparation of the N-benzyl benzene sulfonamide compounds. Compared with the prior art, the method has advantages of evidently higher reaction speed than that of conventional heating, mild reaction conditions, simplicity in operation, high yield, safety, low cost and environmental friendliness.

A synthetic N-alkyl sulfonamide derivatives

The invention discloses a method for synthesizing a N-alkyl sulfonamide derivative. The method comprises the following steps: adding a sulfonamide derivative, a water-soluble catalyst, an alkali, alcohol and a solvent into a reaction container; reacting the reaction mixture at 100-120 DEG C for several hours, cooling to room temperature; performing rotary evaporation to remove the solvent, and then separating by a column to obtain the target compound. The method of the invention starts from the sulfonamide derivative, and obtains the N-alkyl sulfonamide derivative through reaction with alcohol. The method of the invention adopts a water-soluble iridium complex as a catalyst; the reaction is carried out in water; and the target compound is obtained with a high yield. Therefore, the reaction meets the requirements for green chemistry, and the method has wide development prospects.