727-49-1 Usage
Description
HEPTAFLUORO-2-NAPHTHOL, also known as Heptafluoronaphthalen-2-ol, is a chemical compound that serves as a building block and intermediate in the synthesis and characterization of other amino fluoro derived compounds. It is a halogenated aromatic compound with seven fluorine atoms attached to a naphthalene core, which provides unique properties and reactivity.
Uses
Used in Chemical Synthesis:
HEPTAFLUORO-2-NAPHTHOL is used as a building block and intermediate for the synthesis of various amino fluoro derived compounds. Its unique structure and reactivity make it a valuable component in the development of new chemical entities with potential applications in various fields.
Used in Pharmaceutical Industry:
HEPTAFLUORO-2-NAPHTHOL is used as a key intermediate in the synthesis of pharmaceutical compounds, particularly those with fluorinated structures. The incorporation of fluorine atoms can significantly alter the properties and activity of these compounds, leading to improved drug candidates with enhanced potency, selectivity, and pharmacokinetic profiles.
Used in Material Science:
HEPTAFLUORO-2-NAPHTHOL can be used in the development of novel materials with unique properties, such as fluorinated polymers and coatings. These materials can exhibit enhanced chemical stability, thermal resistance, and non-stick properties, making them suitable for various applications, including aerospace, automotive, and electronics industries.
Used in Agrochemical Industry:
HEPTAFLUORO-2-NAPHTHOL can be employed as an intermediate in the synthesis of agrochemicals, such as pesticides and herbicides. The introduction of fluorine atoms can improve the biological activity, selectivity, and environmental persistence of these compounds, leading to more effective and sustainable agricultural solutions.
Check Digit Verification of cas no
The CAS Registry Mumber 727-49-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,2 and 7 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 727-49:
(5*7)+(4*2)+(3*7)+(2*4)+(1*9)=81
81 % 10 = 1
So 727-49-1 is a valid CAS Registry Number.
InChI:InChI=1/C10HF7O/c11-3-1-2(4(12)8(16)7(3)15)6(14)10(18)9(17)5(1)13/h18H
727-49-1Relevant articles and documents
THE PREPARATION AND REACTIONS OF 1,3,4,5,6,7,8-HEPTAFLUORO-2-NAPHTHYL PROP-2-ENYL ETHER: FORMATION OF 1,3,4,5,6,7,8-HEPTAFLUORO-1-(PROP-2-ENYL)NAPHTHALEN-2-ONE AND THE PHOTOLYSIS AND PYROLYSIS OF THIS KETONE
Brooke, Gerald M.,Matthews, Raymond S.,Robson, Nigel S.
, p. 461 - 478 (1980)
1,3,4,5,6,7,8-Heptafluoro-2-naphthyl prop-2-enyl ether (8) was isomerised in boiling xylene to 1,3,4,5,6,7,8-heptafluoro-1-(prop-2-enyl)naphthalen-2-one (9).Photolysis of (9) gave 2,5,7-trifluoro-3,4-(tetrafluorobenzo)tricyclo2,7>non-3-en-6-one (11) (by a addition) and 1,2,7-trifluoro-3,4-(tetrafluorobenzo)tricyclo2,7>non-3-en-8-one (12) (via an initial photochemically-allowed sigmatropic shift).Pyrolysis of (9) at 455 deg C also gave (11), while at 490 deg C, both (9) and (11) gave 1-fluorovinyl 4,5,6,7,8-pentafluoro-1-naphthyl ketone (19).
REACTION OF AROMATIC COMPOUNDS WITH NUCLEOPHILIC REAGENTS IN LIQUID AMMONIA. II. NUCLEOPHILIC SUBSTITUTION IN NITROHALOGENO AND POLYFLUORINATED AROMATIC COMPOUNDS
Shtark, A. V.,Kizner, T. A.,Shteingarts, V. D.
, p. 2051 - 2056 (2007/10/02)
The possibility of aromatic nucleophilic substitution in liquid ammonia was investigated for the case of the reaction of p-nitrochlorobenzene, 2,4-dinitrochlorobenzene, hexafluorobenzene, bromopentafluorobenzene, pentafluorobenzene, and octafluoronaphthalene with a series of charged nucleophiles (potassium hydroxide and sulphite, alcoholates, sodium azide, thiophenolate, phenolate, and sulfide) at -70 to -33 deg C.It was shown that alkyl ethers of p-nitrophenol, phenyl p-nitrophenyl sulfide, 2,4-dinitrophenyl azide, polyfluorinaqted phenols, and their ethers can be obtained with good yields.Comparisons of the results with published data on the rate of the same reactions in other solvents shows that liquid ammonia is highly effective as a solvent for aromatic nucleophilic substitution reactions and in some cases makes it possible to avoid side processes.