727425-40-3

Basic information

• Product Name: 3-bromo-4-methyl-6-phenyl-5,6-dihydro-pyridin-2-one
• Synonyms: 3-bromo-4-methyl-6-phenyl-5,6-dihydro-pyridin-2-one
• CAS NO: 727425-40-3
• Molecular Weight: 266.137
• Mol File: 727425-40-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-bromo-4-methyl-6-phenyl-5,6-dihydro-pyridin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-4-methyl-6-phenyl-5,6-dihydro-pyridin-2-one(727425-40-3)
• EPA Substance Registry System: 3-bromo-4-methyl-6-phenyl-5,6-dihydro-pyridin-2-one(727425-40-3)

Safety Data

• Hazardous Substances Data: 727425-40-3(Hazardous Substances Data)

Upstream product

• 40052-11-7 2-bromo-3-methyl-but-2-enoyl chloride 
• 1578-14-9 2-bromo-3-methyl-crotonic acid 
• 541-47-9 3-Methylbutenoic acid 
• 727425-45-8 3-bromo-1-(4-methoxy-benzyl)-4-methyl-6-phenyl-5,6-dihydro-pyridin-2-one 

Downstream Products

• 727425-41-4 3-bromo-4-methyl-6-phenyl-1-(tert-butyloxycarbonyl)-5,6-dihydro-pyridin-2-one 

Relevant articles and documents

Practical synthesis of 3-bromo-5,6-dihydropyridin-2-ones via β,γ-unsaturated α-bromo-ketene/imine cycloaddition

An approach to 3-bromo-4-alkyl-6-aryl-5,6-dihydropyridin-2-ones and 3-bromo-5-ethyl-6-aryl-5,6-dihydropyridin-2-ones starting from β,γ-unsaturated α-bromoketenes and imines is reported. The presence of a bromine atom on the double bond allows performing aziridination or bromine displacement with an amine. The reaction gave fused bicyclic N-allyl-aziridines or 3-amino-substituted 5,6-dihydropyridin-2-ones, depending on the substituents on the six-membered ring.