72956-44-6

Basic information

• Product Name: O-DESMETHYLCARVEDILOL
• Synonyms: O-DESMETHYLCARVEDILOL;desmethylcarvedilol;2-[2-[[3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]phenol;BM 14242
• CAS NO: 72956-44-6
• Molecular Formula: C₂₃H₂₄N₂O₄
• Molecular Weight: 392.45
• Product Categories: Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Aromatics;Heterocycles;Metabolite
• Mol File: 72956-44-6.mol
• Article Data: 2

Chemical Properties

• Melting Point: 158-160°C
• Boiling Point: 678.7 °C at 760 mmHg
• Flash Point: 364.3 °C
• Appearance: /
• Density: 1.31 g/cm³
• Vapor Pressure: 2.39E-19mmHg at 25°C
• Refractive Index: 1.692
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated), THF (Slightly)
• PKA: 9?+-.0.30(Predicted)
• CAS DataBase Reference: O-DESMETHYLCARVEDILOL(CAS DataBase Reference)
• NIST Chemistry Reference: O-DESMETHYLCARVEDILOL(72956-44-6)
• EPA Substance Registry System: O-DESMETHYLCARVEDILOL(72956-44-6)

Safety Data

• Hazardous Substances Data: 72956-44-6(Hazardous Substances Data)

Usage

Description

O-DESMETHYLCARVEDILOL is a metabolite of Carvedilol (C184625), which is a nonselective β-adrenergic blocker with α1-blocking activity. It is characterized by its chemical properties as a white solid.

Uses

Used in Pharmaceutical Industry:
O-DESMETHYLCARVEDILOL is used as an active pharmaceutical ingredient for the development of medications targeting various cardiovascular conditions. Its α1-blocking activity contributes to its effectiveness in treating conditions such as hypertension and heart failure.
Used in Research and Development:
O-DESMETHYLCARVEDILOL serves as a valuable compound in the research and development of new drugs and therapies. Its unique properties as a metabolite of Carvedilol make it a promising candidate for further investigation into its potential applications and mechanisms of action.
Used in Quality Control and Standardization:
As a metabolite of a well-established drug, O-DESMETHYLCARVEDILOL is utilized in the quality control and standardization of pharmaceutical products. Its presence can be used to ensure the purity, potency, and consistency of Carvedilol-containing medications.
Used in Analytical Chemistry:
O-DESMETHYLCARVEDILOL is employed as a reference compound in analytical chemistry for the development and validation of analytical methods. Its chemical properties make it suitable for use in high-performance liquid chromatography (HPLC), mass spectrometry (MS), and other analytical techniques to ensure accurate and reliable results.

InChI:InChI=1/C23H24N2O4/c26-16(14-24-12-13-28-21-10-4-3-9-20(21)27)15-29-22-11-5-8-19-23(22)17-6-1-2-7-18(17)25-19/h1-11,16,24-27H,12-15H2

Upstream product

• 51997-51-4 4-(2,3-epoxypropoxy)carbazole 
• 1836-62-0 2-(2-methoxy-phenoxy)-ethylamine 
• 72956-09-3 carvedilol 
• 180987-80-8 5-(((9H-carbazol-4-yl)oxy)methyl)-3-(2-(2-methoxyphenoxy)ethyl)oxazolidin-2-one 
• 1479049-26-7 5-[(9H-carbazol-4-yloxy)methyl]-3-[2-(2-hydroxyphenoxy)ethyl]-2-oxazolidinone 

Relevant articles and documents

STORE OVERLOAD-INDUCED CALCIUM RELEASE INHIBITORS AND METHODS FOR PRODUCING AND USING THE SAME

The present invention provides compounds having store overload-induced Ca2+ release (SOICR) inhibitory activity and methods for producing and using the same. In particular, compounds of the invention is of the formula: R1-X1-L-X2-R2, wherein R1, X1, L, X2, and R2 are those defined herein.