730-59-6Relevant articles and documents
Copper-Catalyzed Functionalization of Aza-Aromatic Rings with Fluoroalcohols via Direct C(sp2)-H/C(sp3)-H Coupling Reactions
Chen, Jie,Jiang, Yaojia,Li, Meng,Sun, Wangbin,Zhang, Jinli
supporting information, p. 3033 - 3038 (2020/04/20)
An efficient copper-catalyzed direct C(sp2)-H/C(sp3)-H coupling reaction of aza-aromatic rings with fluoroalcohols is developed. A variety of useful building blocks including hydroxyfluoroalkylated aniline, pyrrole, and indole derivatives bearing a quaternary carbon center could be constructed with high regioselectivity and good to excellent yields under very mild reaction conditions. The reaction is believed to undergo a fluoroalcohol oxidation and to follow an electronic addition reaction pathway.
REACTIONS OF HIGHLY ELECTROPHILIC POLYFLUOROCARBONYL COMPOUNDS WITH PRIMARY ARYLAMINES
Chkanikov, N. D.,Sviridov, V. D.,Zelenin, A. E.,Galakhov, M. V.,Kolomiets, A. F.,Fokin, A. V.
, p. 323 - 328 (2007/10/02)
C-Hydroxyalkylation of primary arylamines by highly electrophilic polyfluorocarbonyl compounds results from the direct reaction of the initial reagents and is competitively inhibited by equilibrium N-hydroxyalkylation.The presence of steric hindrances to
C-ALKYLATION OF N-ALKYLANILINES BY POLYFLUOROKETONES
Zelenin, A. E.,Chkanikov, N. D.,Galakhov, M. V.,Kolomiets, A. F.,Fokin, A. V.
, p. 850 - 853 (2007/10/02)
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