730237-52-2 Usage
Description
1-METHYLINDOLE-3-CARBOXAMIDINE is a chemical compound that is a derivative of indole. It is a carboxamidine, which is a functional group containing a carbon atom double-bonded to a nitrogen atom and single-bonded to an amidine group. 1-METHYLINDOLE-3-CARBOXAMIDINE is known for its unique chemical properties and structure, making it a valuable building block in organic synthesis and pharmaceutical research.
Uses
Used in Organic Synthesis:
1-METHYLINDOLE-3-CARBOXAMIDINE is used as a building block for creating other compounds due to its versatile chemical structure and reactivity.
Used in Pharmaceutical Research:
1-METHYLINDOLE-3-CARBOXAMIDINE is used as a starting material for the production of drugs, contributing to the development of new medications.
Used in Medication Development:
1-METHYLINDOLE-3-CARBOXAMIDINE has potential applications in the development of new medications, leveraging its unique chemical properties and structure to create innovative therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 730237-52-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 7,3,0,2,3 and 7 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 730237-52:
(8*7)+(7*3)+(6*0)+(5*2)+(4*3)+(3*7)+(2*5)+(1*2)=132
132 % 10 = 2
So 730237-52-2 is a valid CAS Registry Number.
730237-52-2Relevant articles and documents
Route to 3-Amidino Indoles via Pd(II)-Catalyzed C-H Bond Activation
Rydfjord, Jonas,Skillinghaug, Bobo,Brandt, Peter,Odell, Luke R.,Larhed, Mats
, p. 4066 - 4069 (2017)
We report a facile synthesis of 3-amidino indoles from indoles and cyanamides. The reaction is Pd(II)-catalyzed and proceeds via C-H bond activation of the indole in its 3-position followed by a 1,2-addition of the resulting indole-palladium σ-complex to a cyanamide, which provides the corresponding amidine. The preference for 4,5-diazafluoren-9-one (DAF) as the ligand is investigated using DFT calculations, and a plausible reaction pathway is presented.
