73083-19-9Relevant articles and documents
Synthesis and structure-activity relationship of novel indene N-oxide derivatives as potent peroxisome proliferator activated receptor γ (PPARγ) agonists
Ahn, Jin Hee,Shin, Mi Sik,Jung, Sun Ho,Kim, Jin Ah,Kim, Hye Min,Kim, Se Hoan,Kang, Seung Kyu,Kim, Kwang Rok,Rhee, Sang Dal,Park, Sung Dae,Lee, Jae Mok,Lee, Jeong Hyung,Cheon, Hyae Gyeong,Kim, Sung Soo
, p. 5239 - 5244 (2008/03/13)
A series of novel indene N-oxide derivatives were prepared by various synthetic methods and evaluated for their ability to activate PPARγ. The best PPARγ agonist in this series was 9 h, which showed an EC50 value of 15 nM.
2,4,6-TRISUBSTITUTED PYRIMIDINES AS PHOSPHOTIDYLINOSITOL (PI) 3-KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF CANCER
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Page 59, (2008/06/13)
Compounds having formula I are provided where the variables have the values described herein. (I). Pharmaceutical formulations include the compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and combinations with other agents. A method of treating a patient comprises administering a pharmaceutical formulation according to the invention to a patient in need thereof.