73101-65-2

Basic information

• Product Name: BENZO[D]ISOXAZOL-3-YL-METHANESULFONYL CHLORIDE
• Synonyms: BENZO[D]ISOXAZOL-3-YL-METHANESULFONYL CHLORIDE;1,2-BENZISOXAZOLE-3-METHANESULFONYL CHLORIDE;Benzo[d]isoxazol-3-yl-methanesulfonyl Chloride, technical grade;1,2-Benzisoxazole-3-methanesulfonic acid chloride;ZonisaMide Chloride;1,2-Benzoxazol-3-ylmethanesulfonyl chloride
• CAS NO: 73101-65-2
• Molecular Formula: C₈H₆ClNO₃S
• Molecular Weight: 231.66
• Product Categories: Aromatics;Sulfonyl Chlorides;Sulfur & Selenium Compounds
• Mol File: 73101-65-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 395.7 °C at 760 mmHg
• Flash Point: 193.1 °C
• Appearance: tan sticky solid
• Density: 1.562 g/cm³
• Vapor Pressure: 4.12E-06mmHg at 25°C
• Refractive Index: 1.631
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility: Acetone (Slightly), Chloroform (Slightly)
• Stability: Hygroscopic, Moisture Sensitive
• CAS DataBase Reference: BENZO[D]ISOXAZOL-3-YL-METHANESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: BENZO[D]ISOXAZOL-3-YL-METHANESULFONYL CHLORIDE(73101-65-2)
• EPA Substance Registry System: BENZO[D]ISOXAZOL-3-YL-METHANESULFONYL CHLORIDE(73101-65-2)

Safety Data

• Hazardous Substances Data: 73101-65-2(Hazardous Substances Data)

Usage

Chemical Properties

Tan Sticky Solid

Uses

Contains approximately 12% dichloromethane and 8% ethyl acetate

InChI:InChI=1/C8H6ClNO3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2

Upstream product

• 73101-64-1 1,2-benzisoxazole-3-methanesulfonic acid sodium salt 
• 10025-87-3 trichlorophosphate 
• 81534-20-5 1,2-benzisoxazole-3-methanesulfonic acid ammonium salt 

Downstream Products

• 68936-32-3 1-(benzo[d]isoxazol-3-yl-methanesulfonyl)-4-phenyl-piperazine 
• 68936-33-4 1-(benzo[d]isoxazol-3-yl-methanesulfonyl)-4-benzyl-piperazine 
• 68936-25-4 C-benzo[d]isoxazol-3-yl-N-(2-hydroxy-ethyl)-methanesulfonamide 
• 68291-97-4 1,2-benzisoxazole-3-methanesulfonamide 
• 68357-44-8 1-(1,2-benzoxazol-3-yl)-N-hydroxymethanesulfonamide 
• 68936-28-7 2-[(benzo[d]isoxazol-3-yl-methanesulfonyl)-amino]-benzoic acid methyl ester 
• 68292-02-4 C-benzo[d]isoxazol-3-yl-N-methyl-methanesulfonamide 
• 68936-43-6 N-acetyl Zonisamide 
• 81534-20-5 1,2-benzisoxazole-3-methanesulfonic acid ammonium salt 

Relevant articles and documents

Green and environment-friendly zonisamide synthesis method

The invention discloses a green and environment-friendly zonisamide synthesis method which includes the steps: adding 1, 2-sulfamethoxazole-3-sodium methanesulfonate or 1, 2-sulfamethoxazole-3-ammonium methanesulfonate into methylbenzene, heating, reflowing and reducing temperature to 10-35 degrees, adding triphosgene and catalysts, heating, stirring and reacting mixture; pumping in a vacuum manner to remove redundant unreacted triphosgene, leading anhydrous ammonia until pH (potential of hydrogen) to be 9-10; centrifuging out solids, leaching the solids by the aid of methylbenzene, adding water to stir mixture, centrifuging and drying the solids, and performing recrystallization for the dried solids by the aid of methyl alcohol to obtain zonisamide crystal. The zonisamide synthesis method is safe, reliable, green, environmentally friendly, high in yield, low in cost, simple in post-processing and suitable for mass industrial production, and raw materials are easily obtained.

PURE 1,2-BENZISOXAZOLE-3-METHANE-SULFONIC ACID SODIUM SALT AND PURIFICATION PROCESS

The present invention provides chemically pure sodium salt of 1,2-benzisoxazofe-3-methane-sulfonic acid, the sodium salt of 1,2-benzisoxazole-3-methane-sulfonic acid of high assay, or chemically pure sodium salt of 1,2-benzisoxazole-3-methane-sulfonic acid of high assay, and processes for preparing the same via purification. The present invention also provides monohydrate form of the chemically pure sodium salt of 1,2-benzisoxazole-3-methane-sulfonic acid, the sodium salt of 1,2-benzisoxazole-3-methane-sulfonic acid of high assay, or chemically pure sodium salt of 1,2-benzisoxazole-3-methane-sulfonic acid of high assay. Furthermore, the present invention provides anhydrous form of the chemically pure sodium salt of 1,2-benzisoxazole-3-methane-sulfonic acid, the sodium salt of 1,2-benzisoxazole-3-methane-sulfonic acid of high assay, or chemically pure sodium salt of 1,2-benzisoxazole-3-methane-sulfonic acid of high assay. One of the embodiments of the present invention is directed to a process for preparing zonisamide using the chemically pure sodium salt of 1,2-benzisoxazole-3-methane-sulfonic acid, the sodium salt of 1,2-benzisoxazole-3- methane-sulfonic acid of high assay, or chemically pure sodium salt of 1,2-benzisoxazole-3-methane-sulfonic acid of high assay.

Process for the preparation of zonisamide

The present invention provides an improved process for the preparation of zonisamide or a derivative thereof comprising (a) reacting 1,2-benzisoxazole-3-methane-sulfonic acid with a halogenating agent in a first organic solvent to provide benzisoxazole methane sulfonyl halide; and, (b) reacting benzisoxazole methane sulfonyl halide with an amine in a second organic solvent to form zonisamide or a derivative thereof.